MacGyver attempts to get a reporter out of a Central American country with evidence linking a general to an illegal arms dealer. As MacGyver and Kate reach the border, it is clear escaping to Mexico will be no easy task, as the general and the arms dealer have every imaginable route severely guarded. There is no turning back. MacGyver must figure out how to get across the border, as his life, as well as Kate's, hangs in the balance.
When $60 million worth of stolen diamonds destined for a relief charity end up in the hands of casino owner Jack Catlin, MacGyver must head to the Virgin Islands to try and get them back. With the help of Chris Rhodes, a senator's daughter, MacGyver masterminds a plan to break into Catlin's vault and steal them back.
A mysterious person, who calls himself "Viking", has just bombed a cruise ship. He demands six million dollars or another bomb will go off within hours. So MacGyver, with an old friend from Vietnam, Charlie Robinson, is sent to disarm it. But when they get there, they find out there's more then one bomb on the ship.
MacGyver is on his way out of Bulgaria with a secret microfilm, when he meets Penny Parker, a beautiful, talkative American, who is on the run from her lover, a man named Stephan Frolov. She stashes some jewels on MacGyver, thus making him a suspect, and now MacGyver and Penny must flee Bulgaria together.
MacGyver and Pete are testing a new security system at the Strategic Research Development Administration. MacGyver successfully bypasses the security and meets Dr. Jill Ludlam, the system's designer. She tries to turn off the security system, but it doesn't realize that it was just a test. MacGyver and Dr. Ludlam are then forced to find a way out, as the security system, named Sandy, tries to destroy the "intruders."
MacGyver and Pete have a surprise party planned for a colleague, but when the colleague doesn't show up, MacGyver goes looking for him, and finds him on the verge of committing suicide. When questioned why he would do such a thing, Kelly explains that a con artist has swindled him out of his life savings. MacGyver tells Pete about Kelly's situation and the two of them decide that they will get Kelly's money back from the con
While MacGyver goes to pick up a Chinese friend's brother from a birthday party, he witnesses something strange: Paul is being called "The Wish Child." It seems that a greedy businessman has wrapped him up in a scam, because he looks exactly like a boy from an old legend that owns the secret of immortality. Now, MacGyver must try to talk him out of this, because Paul is starting to believe he really is The Wish Child!
MacGyver goes to the mountains to lead four ex-gangster teens on a Phoenix Foundation funded rehabilitation trip. When he gets there, he finds that this task may be a little more complicated then he thought. All of the kids are very rebellious and one of them has a bad grudge against another one. A couple of days later when MacGyver is returning with the kids, their plane crashes in the middle of the wilderness and one of them is injured. Now, MacGyver must fix the plane and help the kids work out their differences so they can save their friend.
MacGyver and Pete head to Asia to rescue a nun, who is an old friend of Pete's, and the orphaned children she takes care of from aggressive regime troops. While there, MacGyver runs into someone he never expected, his old fiancee, Debra. Now MacGyver must complete his mission, work out his differences with Debra, and escape from the troops, all before the troops find them.
While helping the Phoenix Foundation test a new missile-guidance system for the government, MacGyver's efforts are hampered by men who are trying to steal it. When the men escape with it, MacGyver turns to his deaf friend, who has been having premonition-type dreams of this happening. Now MacGyver must try and analyze her dreams so that he can find the men who stole the system.
A retired actor and his wife stop at a motel on the way to Los Angeles. MacGyver rescues them from a drunkard who nearly makes a mark on their car. MacGyver is supposed to meet a mobster-turned-informant at the motel, but the meeting goes wrong. The mob shows up and kills MacGyver's friend before he can give MacGyver what he promised. Instead the bag lands in the old couple's car, where the old actor finds it and discovers it full of money.
While retrieving tickets for a hockey game at the Phoenix Foundation, MacGyver and his grandpa Harry get caught in the middle of a woman's plot to blow up the building using a bomb that she herself made. They try to escape, but are locked in. Now they must figure another way out before she activates the bomb.
MacGyver puts up Penny Parker for a few days while she's looking for a job as a singing telegram. But on her first day, she happens to witness two thugs torturing a man. Unfortunately, she can't find her way back, and when she does, MacGyver thinks this may be the start of something bigger as the victim is a Federal agent.
While on an expedition to find a Spanish treasure fleet, Dr. Barbara Ortega's boat is hi-jacked by modern-day pirates. They steal the small amount of treasure that she has already found - including the ship's log, which is the key to finding the whole fleet - and take off. When she makes it public that she was hi-jacked, the Phoenix Foundation sends MacGyver to help. Now, MacGyver and Barbara must recover the ship's log, so she can find the treasure before the pirates do.
When MacGyver and Pete go skiing, a man switches poles with MacGyver, only moments before being gunned down and killed by his former friends. But the gunshot starts an avalanche, which covers MacGyver completely, leaving it up to Pete to convince the mountain rangers to stage a search and rescue before the next avalanche comes. As MacGyver finally is dug up, the gangsters are there, waiting for him, and whatever is hidden in that ski pole.
MacGyver is called to a meeting with a former British spy, who has learned of a group of terrorists that will use a new plastic explosive in a vengeful attack on the U.S. army. This explosive can be hidden anywhere. However, before the spy can give MacGyver all the details he is shot. MacGyver flees through a window and is picked up by a boat. The female who owns the boat soon learns that the man she has rescued doesn't have any memory.
MacGyver teams up with colleague Nikki Carpenter to find out who is behind the attempts on her life. When they find out that the man who tried to kill her is connected to two terrorists who blew up a local post office, MacGyver and Nikki must find out what the terrorist's next target is before it's too late.
While testing a new nuclear bomb defusing team at the Phoenix Foundation, a deadly explosion kills three men. Pete blames himself for not inspecting their equipment better and resigns from his job out of guilt. However, Pete is replaced by a not-so-trustworthy man—one who may have been connected to the explosion.
While back in Minnesota to fill in as coach for a high-school hockey team, MacGyver tries to change the attitude of a callous player who has a shot at playing for the pros. But when this kid's ambition lands another player in the hospital, MacGyver must try and find out what or who is pushing him so hard to succeed.
After returning home from a long assignment, MacGyver has an unwelcome surprise. Jack Dalton is waiting and wants him to help with a new scheme. A wealthy woman has just acquired some invaluable jewels, needing Jack to fly her back to her home in France. Things seem to be going fine, that is, until they land. Jack and MacGyver are arrested and accused of theft.
While visiting an old girlfriend who's a park ranger at a wildlife reserve, MacGyver runs into deadly poachers who are intent on hunting animals on the reserve. When MacGyver tries to uncover their plot, they come after him. Now it's a race against time to escape the poachers, save the animals, and save their own lives.
MacGyver accompanies his friend Penny Parker to an old house she has inherited from her Aunt Betty, who mysteriously died 30 years before. When strange things start happening, Penny is sure that the house is haunted. However, MacGyver tries to convince her that there's no such thing as ghosts, but then he starts witnessing the strange events, too.
While on assignment for the Phoenix Foundation to test field agents to make sure they are still in shape, MacGyver finds out he now has another agent to test: Pete. Things take a turn for the worse when MacGyver and Pete head into the wilderness where they stumble upon a wrecked plane and pictures of two dangerous drug smugglers who shot it down.
When Pete's son, Michael, returns to work for the foundation, neither Pete nor MacGyver see that Michael has used his connections to get closer to a Phoenix Foundation technology system in order to steal it and to sell it to the mysterious Papillion. But Papillion has plans of his own for Michael and his gang.
MacGyver heads up a trip with four other Phoenix Foundation employees into the wilderness as part of a stress reduction program. After discovering that a prison bus accident has freed several prisoners, the employees begin to question each other's behavior. MacGyver must now figure out which man, if any, is not to be trusted before it's too late.
Mac helps out on an archelogical dig for Alexander the Great's tomb. But the expedition seems to be followed by bad luck. Several incidents nearly causes a shut-down. Then Mac finds clues leading to Alex's tomb. Unfortunally, the accidents are not coincidental, and they meet a very vengeful man who traps them inside the grave...
While researching his family's genealogy, MacGyver discovers that his family name was disgraced during the Middle Ages. He is then knocked unconscious and, not surprisingly, is transported through dreams to the time of King Arthur. Here he must confront some stubborn knights, convince Arthur that he is a friend, and set out in search of his forefathers.
The 10-minute commercial, in which Richard Dean Anderson provides voiceover for his character’s thoughts and actions, harkens back to early episodes of the MacGyver television series.
Angus Macgyver’s nephew quits school and joins The Phoenix Foundation. But he finds it difficult to follow in the shoes of his famous uncle.