Charlie Harris, the charismatic Chief of Surgery of Toronto’s Hope-Zion Hospital, ends up in a coma, leaving the hospital in chaos – and his fiancée and fellow surgeon, Alex Reid, in a state of shock. As the action unfolds, comatose Dr. Harris explores the hospital halls in “spirit” form, not sure if he's a ghost or a figment of his own imagination. Reid, along with her fellow doctors, press on to save his life and those of their other patients, as they deal with the complicated and courageous decisions that are made in their daily struggle to keep hope alive.
When a severely injured man under the spell of hypnosis cannot remember his identity, the hypnotist who put him under is called into the hospital – where he uses his psychic ability to connect Charlie and Alex. Meanwhile, a young woman comes into the E.R. with a neck injury, but it’s Hope Z’s psych resident, Gavin who knows how to help her.
A routine surgical procedure goes awry when Alex’s patient, a soon-to-be-wed young woman, falls into a coma. While Alex struggles with a case that hits close to home, Joel treats a patient who does his own body modifications, and Charlie finds himself drawn to Alex’s coma patient in the spirit world. Meanwhile, a young woman comes into the E.R. with a neck injury, but it’s Hope Z’s psych resident, Gavin who knows how to help her.
With Charlie's life hanging in the balance, Alex and Dawn go head-to-head over who gets to be his legal decision maker – but are forced to put personal matters aside when they scrub into a heart transplant surgery together. Charlie, meanwhile, is in no mood to talk to the heart donor – a deceased prisoner.
With Charlie removed from his ventilator, all he and Alex can do is wait and ask themselves: is this really it? But when a patient comes in for a routine follow-up, her new symptoms could lead Alex and Charlie to making a discovery about Charlie's coma. Meanwhile, Joel cannot operate after breaking his hand, and Maggie and Gavin deal with the aftermath of their kiss.
When Joel gets cold feet in the OR, Kinney takes him with her to her hometown to help clear his head. During their field trip, a woman gets pinned underneath a truck and Joel and Kinney lead the rescue effort. Meanwhile, Charlie meets a newly deceased therapist who suspects it's an emotional block that is keeping him in his coma.
Alex and Charlie are caught in the middle of a shooting on their way to their first shift back at Hope Zion. In the midst of the commotion, Alex treats a bullied teenager and deals with her own emotions about everything that’s happened in the past year. Meanwhile, Charlie is caught off guard when he realizes that he’s still able to see the spirits of deceased patients. As well, new Chief of Surgery Joel works alongside Charlie’s ex-wife Dawn to perform an intense surgery.
Alex must learn to stick up for herself and not be intimidated by Dawn (Charlie’s ex-wife) in order to work alongside her and perform a minimally invasive heart procedure to save a patient’s life. Meanwhile, Joel unlocks a mystery to a young girl’s disease, while getting some advice from Charlie, who is trying to figure out how to help his comatose patient come back from being a spirit. It’s a week of defying the odds at Hope Zion Hospital.
Alex is trying to get her life back to normal with Charlie and at Hope Zion Hosital – but with Charlie’s head in the clouds and the pressure to find her medical niche – she’s struggling. Inspiration comes in the form of an immigrant doctor who needs Alex to save his wife’s life, and in return, helps her find her calling.
The doctors at Hope Zion Hospital are forced to deal with people from their past as Alex, Charlie and Joel take on the daunting task of operating on a malpractice lawyer known for suing every doctor in his path. Meanwhile, Zach is tested when the last person he wants to treat comes into his E.R. and a Season 1 patient returns with some difficult insight for Charlie and Alex.
Alex must become the unlikely advocate for a violent young prisoner brought in to Hope Zion Hospital, while Joel connects with a disfigured refugee and tries to convince Dr. Dana Kinney to come back to operate on him. Meanwhile, a spirit who is familiar to many Hope Zion doctors shows up in the morgue when Charlie is about to do routine procedure.
After a young, healthy and hunky fireman dies suddenly at Hope Zion Hospital, Alex must take the stand at Hope Zion’s Morbidity and Mortality (M&M) Rounds to find out what went wrong and who is to blame. Meanwhile, Charlie deals with a nervous aspiring Nun, and Joel has to decide if he can be the man that comes through for Sonja.
When a heat wave hits the city, Alex is appointed Trauma Team Leader as the hospital is faced with an influx of patients during a blackout. With no back-up power available, Dawn and Charlie must figure out a way to continue their surgery as Joel and Maggie attempt to keep a patient alive while stuck in an elevator.
When Alex and Joel end up stranded in the middle of nowhere with a severely injured couple, they’re forced to use only what’s around them to stabilize the pair until paramedics arrive. Meanwhile, back at Hope Zion Hospital, Charlie must try to save the wounded leg of his former college roommate as Gavin attempts to help Shahir improve his bedside manner.
When Alex is forced to put a patient’s gender reassignment surgery on hold, she discovers a secret in his medical history that could save his surgery, but tear his life apart. Charlie deals with a patient who is healthy, sane – and convinced she is going to die at midnight. Meanwhile, Joel secretly helps Sonja deal with a patient of hers who’s been admitted to Hope Zion Hospital.
When Alex’s brother Luke is admitted to Hope Zion Hospital in critical condition, Joel and Charlie must work together to keep him alive while keeping his admittance a secret from Alex. Meanwhile, Alex figures out a way to remove a tumour from a patient pregnant with twins, while Maggie is thrown off her game by the patient’s gorgeous OB/GYN.
With one of the Hope Zion doctors’ life at risk, Alex must put her personal and professional reservations aside in order to perform a surgery that could save their life. Meanwhile, a patient's routine check-up proves deadly, and Joel is left to uncover a medical conspiracy that extends far beyond Hope Zion Hospital. Charlie attempts to help Joel unravel the mystery, but ends up preoccupied with helping his patient's spirit.
Alex is surprised twice in one night – first when she realizes she's been tricked into a blind double date, and again when she has to rush her mystery man to the ER. Meanwhile, Charlie works to help a soldier move past a traumatic experience, and Maggie discovers a patient has a contagious illness that could put her pregnancy at risk.
Alex is on her way home to unwind after a long day at work – but all that changes when she witnesses a traumatic accident and is forced to return to work, where the Hope Zion Hospital doctors must work tirelessly against the clock to save a problematic John Doe. Meanwhile, Charlie and Gavin explore Charlie's relationship to the Spirit World in a therapy session.
Buried secrets come to light as Alex treats an elderly patient whose unusual symptoms have her convinced she’s living in a different era. Charlie and Joel get competitive as their patients pit their surgeons against each other. And Maggie agrees to shadow Dr. Kalfas for a surgery, but has to take the reins when complications arise.
After Dawn diagnoses her with an irregular heartbeat, Alex is supposed to be resting up – but before she gets the chance, The Great Randall returns to Hope Zion Hospital after an experimental cancer treatment gone wrong. Meanwhile, Charlie struggles with the implications of his fight with Joel, who is trying to treat a troubled mathematician.
Charlie (Michael Shanks) tries to comfort spirit Alex (Erica Durance) in the OR as they watch Dawn (Michelle Nolden), Maggie (Julia Taylor Ross), and Reycraft (K.C Collins) struggle to repair her heart. Before spirit Alex can fully comprehend that she’s dying on the operating table and that Charlie really can see ghosts – she pops – waking up in a “dream” that takes her back to her childhood home in St. Catharines, Ont. A chance encounter with a lost loved one puts Alex face-to-face with a repressed memory that holds the key to her past, present and future. Meanwhile, Dawn (Michelle Nolden) manages to stitch the hole in Alex’s heart, only to be convinced by a passionate Charlie that something may still be wrong with Alex – leading the team to discover a deadly mistake that Dawn has only minutes to rectify. Joel (Daniel Gillies) is pulled to the ER to treat Alex’s assailant – and when his patient pleads to let him die – Joel’s morals as a man are tested against his ethics as a doctor.
Alex Reid (Erica Durance) is still in a coma, and her impatient spirit wants her to wake up. Charlie Harris (Michael Shanks) encourages spirit Alex to let her body recover and enjoy the time they have together in the ‘spirit-world.’ Charlie and Joel Goran (Daniel Gillies) come face-to-face for the first time after their fight, and Alex feels for Joel, who still very much blames himself for her accident. Joel welcomes a distraction when he is called to treat the necrotic leg of an animated drug addict. Still searching for redemption, he makes a pact with the patient to see him through this ordeal, and when an unexpected obstacle arises, he finds himself deeper into his downward spiral. Meanwhile, Maggie Lin (Julia Taylor Ross) and her new boss, the militaristic and pragmatic Dr. Sydney Katz (Stacey Farber), treat a five-month pregnant woman who suffers an aneurysm in the hospital, which renders her brain-dead. The woman’s spirit pleads with Charlie to convince her husband to fight for the life of their son inside of her. After witnessing the couple’s parental love, Alex discovers she wants to become a mother.
Alex Reid (Erica Durance) is awake, but still not back to her old self. She feels like a stranger in her own hospital. Dawn Bell (Michelle Nolden) has given strict orders for her recovery plan, much to the chagrin of a restless Charlie Harris (Michael Shanks). Throughout the day, Alex is visited by the staff of Hope Zion Hospital, but in the end, it is a patient who gives her the opportunity she needs to truly make progress. Meanwhile, Charlie and Joel Goran (Daniel Gillies) square-off over differing treatment options, when two fused-together burn victims are brought into the ER. More heat is added to the fire when Charlie discovers Joel has been visiting Alex on a regular basis. Meanwhile, Maggie Lin (Julia Taylor Ross) finds herself in a whirlwind of emotions triggered from the fallout of her miscarriage, and it seems every doctor has their own ideas on how to best manage her outbursts. Plus, a menacing ghost presence has Charlie on edge.
Charlie and Alex try to navigate their way back as a couple, as Alex faces her first day back as a doctor at Hope Zion Hospital. It is none other than the Chief of Surgery, Dawn Bell, who will act as a "buddy colleague" during her rounds. Dawn comes to realize that she may also have some unresolved issues relating to Alex’s stabbing. Meanwhile, Charlie is visited by one of the happiest spirits he’s ever encountered. While trying to be a Good Samaritan, Joel unexpectedly finds himself in the middle of a hostage situation at a local street clinic. Psychiatrist Dr. Gavin Murphy meets a new colleague at Hope Zion, who is able to help him navigate his feelings – leading to some welcomed “enlightenment.”
A car accident brings a ‘she‐bear’ mother and her son to the hospital. Alex Reid (Erica Durance) and Joel Goran (Daniel Gillies) discover the mother is in need of a transplant – and her son is very adamant that he be involved in the surgery. Dawn Bell (Michelle Nolden) instructs them on procedure and, before they know it, the trio are brought before an ethics panel – including one very unconvinced psychiatrist. Meanwhile, the mother’s spirit is determined to get Charlie Harris (Michael Shanks) to do her bidding, which includes stepping out of his comfort zone when console her son. Then, Charlie finds himself pulled into the ER to help Zach Miller (Benjamin Ayres) with a patient whose obsession might cost him his life. Plus, new resident Rian (Danso Gordon) and Maggie Lin (Julia Taylor Ross) search the hospital for Hope Zion’s very first “code crown,” which results in having to answer to a shaken Dawn.
A devastating accident requires the help of Hope Zion Hospital’s doctors at an offsite army base, and Dr. Charlie Harris (Michael Shanks) and Dr. Joel Goran (Daniel Gillies) flip a coin to decide who will take the call. When Joel wins the toss, he and Dr. Zach Miller (Ben Ayres) depart for a heart-pounding day as they attempt to save the life of a soldier in dire circumstances. Meanwhile, Charlie and Dr. Dawn Bell (Michelle Nolden) work to save a victim of hypothermia, and it’s do or die time for Hope Zion Hospital’s surgeons-in-training when Dr. Alex Reid (Erica Durance), Dr. Maggie Lin (Julia Taylor Ross), and Dr. Rian Larouche (Danso Gordon) finally face the future and their Surgical Boards. But for Alex, the biggest day in her career is also about to become the biggest day of her life.
A bomb explodes during a charity run and the majority of victims are brought to Hope Zion Hospital, including some staff.
Alex is distraught that she unknowingly helped the bomber at the expense of a friend.
When an ice storm strikes the city, Alex and Dawn struggle to keep a good Samaritan alive long enough for her family to say goodbye.
When a chef with oral cancer refuses care, Alex must confront her own feelings about the way Dana is handling her treatment.
Kristine shows up at the hospital with baby Luke's blanket.
Alex and Jeremy try to solve a child's mystery illness; Charlie treats an actor; Maggie reaps the rewards of compassionate medicine.
Charlie decides to go a day without using his special abilities; Alex organizes a trip to Dana's cabin; Zach takes control of a life and death situation involving Dawn's college roommate.
Alex and Cassie team up to free a young woman from an abusive partner, while Dawn deals with a series of life-threatening complications due to a patient’s malfunctioning pacemaker.
First part of a 2-hour season finale. Charlie's condition proves more dangerous than initially thought, as Alex and Shahir struggle to save his life.
Second half of a 2-hour season finale. Charlie's condition proves more dangerous than initially thought, as Alex and Shahir struggle to save his life.
While searching for Charlie, Alex finds a caterer who was caught in the crossfire; Grace's mother asks for a priest; Dana consults with Cassie about a male stripper.
Alex and Charlie are confused about their relationship; Alex and Maggie disagree about a car crash survivor; Dana is forced to treat an injured motorcyclist; Zach bothers Maggie about dating.
Alex makes a promise to a young girl on her birthday; Maggie organizes a surprise party for Alex; Cassie is forced to confront her fear of infectious diseases.
Tempers flare as Dev’s med school rival arrives at the hospital; Alex puts her job in jeopardy to help save the life of an at-risk youth.
Alex tracks down the father of a patient who needs a liver transplant; the new CEO of Hope Zion is at odds with Dawn; Zach faces trials in the E.R.
Alex's alarm at home goes off; Alex and Maggie ask Charlie for his opinion on a patient's treatment; Zach is persuaded by a patient while transitioning the ER to an urgent care facility.
Alex and Maggie deal with a tough lawyer after surgical complications with their cancer study patient; with the E.R. now an urgent care facility, Zach and his team aren't equipped to handle an accident victim.
Charlie and Manny treat a couple; Maggie evaluates the interns; Billy asks Maggie to be his mentor; Dawn tries to get her Chief of Surgery position back.
The doctors rally together to try to save an unknown man who was struck by a subway train; Charlie realizes who the John Doe is.
Alex tries to distract herself from her grief; Charlie and Shahir try to track down Alex's brother.
While Charlie tries to save a young man's life, he is haunted by a mischievous spirit.
Alex and Maggie work together to deliver a baby; Charlie treats a magician.
Alex tries to help patient who hurt himself breaking into a house; a friend of Dr. Dev Sekara has been beaten by the police; a heart patient wishes to open an animal sanctuary.
Alex is challenged about the value of holistic medicine; Charlie's abilities are questioned; two filmmakers go to Hope Zion Hospital
The board questions the hospital staff about Charlie's behaviour; a patient convinces Alex to use new-age techniques; Shahir agrees to do an in-utero surgery.
Alex has to put her concerns for Charlie aside when a chance to perform a cancer surgery arises.
Alex and Charlie put their wedding plans aside; Zach takes a special interest in a case; a coma patient who wakes up with no memory.
Following a mass casualty accident involving a bus full of teenagers, Alex & Charlie rush to the scene to try and save the kids while waiting for backup to arrive. The Hope Zion Hospital family must band together to overcome the tragedy and move on to the next chapter of their lives.