Christmas is just around the corner and the nuns and midwives of Nonnatus House are busier than usual. After an abandoned baby is found on the steps of the convent, the whole community comes together to offer food and clothing and attempt to locate his mother. Jenny Lee ends up getting caught up in a mystery that surrounds an elderly local woman called Mrs Jenkins. Chummy attempts to pull out all the stops to stage a memorable children's nativity play.
Jenny is seconded to a short-staffed hospital in London, but grows increasingly reluctant to carry out her duties when she finds out she is working under intimidating surgeon Mr Tracey. Back in Poplar, the midwives are introduced to newcomer Jane and outspoken twins Meg and Mave Carter. The sisters are identical in every way, except one of them is now pregnant - forcing them to come to terms with the impact a baby will have on them.
Cynthia has to administer daily insulin injections to diabetic John Lacey, a bully who consistently belittles his wife Annie. When Annie’s beloved son Bob pays a visit, Annie gains the confidence to start to turn her life around. Jenny looks after a black mother to be, Monique, who is subjected to racial prejudice from her neighbours.
1958 is drawing to a close as the residents of Poplar prepare for Christmas. Festivities are thrown into chaos when an unexploded bomb is discovered close to Nonnatus House, causing mayhem among the nuns, midwives and residents of Poplar just days before Christmas. Everyone is evacuated from their homes, and the midwives of Nonnatus House are tasked with overseeing the rescue centre until the bomb is made safe. Jenny Lee finds herself drawn into the lives of young couple Yvonne and Alan Bridges, who are expecting their first child. Since fighting in the Korean War, Alan has suffered from post-traumatic stress disorder and Jenny, with the help of Trixie, becomes instrumental in helping him to overcome his fears. Elsewhere, Shelagh Mannion, formerly Sister Bernadette, and Dr Turner prepare for their understated wedding. But when Timothy is struck down with a potentially fatal illness, their plans are put on hold while they keep vigil at his bedside.
After the closure of Nonnatus House, the nuns and midwives finally move into their new premises. Sister Winifred arrives from the Mother House. Jenny is worried about new mother Merle’s mental state and the welfare of her baby who isn't feeding properly. Dr Turner is worried that it could be something more serious.
Trixie's feathers are ruffled when Jenny is promoted, but the new Acting Sister has more to worry about after a mother-to-be reveals the baby she is carrying doesn't belong to her husband - and to complicate matters, the real father is black. Cynthia is inspired by a lecture on natural childbirth, convinced it will help an overly anxious patient, while Alec and his friends try to persuade Jenny to join them on a CND march.
Sister Julienne receives an SOS from Holloway Prison, whose usual maternity workers have been struck down by illness, and when she and Trixie step in to help, the nun puts her reputation on the line to prevent a heavily pregnant convict having her unborn baby taken away by social services. Shelagh faces heartache when a routine pregnancy check reveals something far more serious, Alec has a confession for Jenny and Fred takes the gang to the theatre to celebrate Chummy's birthday - only for the trip to end in disaster.
Jenny has an eventful few days, starting with a patient who as well as having herself to worry about, is also struggling to cope with her mother, an agoraphobic who hasn't been outside for at least 12 years. On top of that, Alec asks the midwife to accompany him to Brighton for the weekend, leaving her wondering if his intentions are strictly honourable. However, things soon take a tragic turn. Meanwhile, Shelagh joins the local choir to take her mind off her problems.
The nuns and midwives are busy preparing for Sister Evangelina's surprise jubilee celebrations, marking 50 years since she took her vows, but a face from the past threatens to ruin the party for the guest of honour. It's back to business when a young woman with Down's syndrome is brought in feeling unwell. To everyone's surprise, they discover she is six months pregnant, causing some of them to think the worst, and the staff are joined by new nurse Patsy, whose sense of humour and no-nonsense attitude make her an instant hit.
Sister Julienne calms an anxious new mother who has put her baby in danger. Jenny, seconded to The London, is impressed with the facilities, but soon begins to see cracks in the establishment. Chummy is upset to learn that her mother has walked out on her father, leaving Lady Browne penniless. As Dr. Turner and Shelagh continue the adoption process, they uncover a devastating secret.
Jenny is assigned to first-time mother Jeanette, who requires frequent visits during a protracted labour, and when she meets her patient's cousin, Philip, a new friendship begins to grow for the midwife. Meanwhile, Chummy worries about her mother's illness when she discovers Lady Browne has discharged herself from hospital.
Jennifer prepares for Christmas at home with Philip, and reminisces about her friends and colleagues back in her youth. Rehearsals get underway for the Sunday School Christmas concert, as Chummy tries to choreograph the dancing snowflakes. Chummy is also enlisted alongside Patsy to run a poorly managed mother and baby home. Cynthia is drawn into a case which concerns two former residents of a Victorian mental hospital who have been left to fend for themselves.
Barbara faces her most challenging case to date when she treats first-time mother Abigail Bissette and the birth does not go according to plan. As Sister Julienne struggles with the increasing financial pressure on Nonnatus House, a mystery benefactor comes to the rescue. Elsewhere Sister Evangelina is unimpressed by newly arrived nurse Phyllis Crane.
When a baby is born with severe deformities of the kind later identified as caused by the drug thalidomide, the midwives find it difficult to handle the situation, and the baby's father rejects her completely, to his wife's dismay. Trixie's new sideline as a keep fit instructor brings her into conflict with Sister Julienne, and she also becomes suspicious of the relationship between Barbara and Tom. Rather than return to Wales as her mother wishes, Delia moves into Nonnatus House.
Barbara treats a pregnant woman whose dockworker husband is struggling to support her as opportunities for work dry up. She is forced into a difficult decision that leaves Barbara facing the biggest test of her career. Nurse Crane meets a kindred spirit when she learns to speak Spanish, and Sister Evangelina helps a woman with breastfeeding, leading to unforeseen consequences.
A outbreak of typhoid erupts, and suspicion over who the carrier could be threatens to break apart a closely knit family. Sister Winfred faces a personal dilemma when a local teacher is revealed to be pregnant by a married man. When the woman takes matters into her own hands, Sister Winifred is forced to consider the role her own prejudices may have played. Meanwhile, Barbara inadvertently agrees to go to dinner with Tom, but is wracked with worry about how Trixie will react.
Sister Julienne is seconded to a maternity ward, and is impressed by how modern technology is being used to help the mothers - but is left with a moral dilemma after assisting on a traumatic birth. A young man from Poplar is delighted to be accepted into university, but his mother is less than happy. His dreams are jeopardised when his girlfriend gets pregnant, a development that puts pressure on the whole family.
Turner and Shelagh are at the forefront of the advances in medical technology, and begin a campaign to ensure better respiratory health for their patients. However, Timothy fears their own lifestyle is not good for them and tries to encourage his parents to give up smoking. Violet injures her back and is forced to leave the shop in Fred's hands, a decision that strengthens their relationship but which proves to have other, unforeseen consequences. A new mother's past comes to light, with devastating repercussions for her family. Nurse Crane draws on her own experiences to help her.
Poplar is rocked by a series of violent attacks on women, and a prostitute is too ashamed to report what she knows - but her actions lead to a dangerous man roaming the streets, with devastating consequences for the residents of Nonnatus House. A mother tries to keep her daughter's pregnancy a secret to avoid gossip, putting her life in danger. The Turners go on a long overdue holiday, but the weather ruins their plans.
The introduction of the contraceptive pill is welcomed by Dr Turner, but some of his colleagues are less keen on the idea. Patsy tries to help a bargee who wants to give birth among her own community rather than in a maternity ward. Nurse Crane deals with an emergency during a storm, and a familiar face returns to Nonnatus House - but has been changed by her time away.
Dr Turner is horrified to realise he may be partly to blame as the cause of the recent rise in birth deformities comes to light, and tries to prevent further cases. Sister Evangelina returns to work, but has clearly been affected badly by her stroke, and her health continues to deteriorate. A pregnant bride goes into labour during her wedding reception, while her mother is forced to come to terms with her grandchild being conceived out of wedlock.
Documentary in which Stephen McGann, who plays Dr Patrick Turner, explores the social and medical changes that took place in the 1950s and 60s relating to childbirth. Along the way, Stephen meets midwives, nuns and doctors who helped deliver babies during the period. As well as archive footage and expert interviews, the programme features clips from past editions of Call the Midwife, footage of the new sixth series and an interview with creator and writer Heidi Thomas.
Boxing Day sees heavy snowfall covering the country and the adverse weather causes major disruption across Poplar as roads become blocked and pipes freeze meaning families have to queue outside for water from standpipes. Sister Julienne must inform a family about the death of their loved one and uncovers an uncomfortable truth, while Valerie helps an unmarried couple living in a caravan prepare for their baby, but unforeseen complications knock her confidence in her ability as a midwife. Guest starring Anita Dobson.
A new midwife joins the team as the area is rocked by power cuts and blizzards. The new arrival is delayed by the weather and falls ill as soon as she arrives. However, she is quickly dragged from her sick bed to assist with a difficult birth. Nurse Crane and Dr Turner treat an elderly cancer patient who faces losing her house due to slum clearances, and try to convince Sergeant Woolf to allow her to die at home.
Valerie's friend Marjory goes into labour while Lucille is on duty, and the new recruit successfully delivers the baby. However, when Marjory's health takes a turn for the worst, her racist mother Mae accuses Lucille of incompetence. The nurses rally round to protect their new colleague, and convince her that she is welcome in the community. Sister Winifred comes up with a plan to get fathers more actively involved in their wives' pregnancies - but finds that very few of the local men are keen on the idea.
Nurse Crane and Trixie investigate when a mother abandons her children at the clinic, fearing they were being abused or neglected. Her husband admits that she has been behaving strangely lately, and when she is referred to a neurologist by Dr Turner, the truth proves devastating for the whole family. Christopher admits that Alexandra has been unhappy since his divorce, and Violet and Fred organise a beauty contest to raise money for charity. Valerie and Magda both sign up and quickly become close friends - leading to the sharing of a terrible secret.
Sister Julienne helps a woman from Pakistan who is unable to have children, but who has found to her shock that her husband is bringing a second wife into their home, who is already eight months pregnant. Trixie hits the bottle following her break-up with Christopher, Dr Turner tries to persuade Sister Monica Joan to admit that her eyesight is failing, and Lucille helps a woman with a compulsion to eat coal.
Rumours spread around Poplar that a sailor with smallpox is hiding somewhere in town. Nurse Crane and Dr Turner try to track him down before he causes an outbreak. Lucille treats an expectant mother on her own, but soon feels out of her depth when she displays signs of a serious medical condition. Trixie goes to stay with her godmother, Violet and Fred organise a picnic for the parish, and Tom and Barbara return home.
Barbara helps a pregnant mother-of-two whose husband has recently died, and is on hand to give her support when a further tragedy drives her and her children from their home. Lucille teaches a health and relationships class at the youth club, only to encounter a furious mother who objects to her daughter attending. Sister Monica Joan goes into hospital for cataract surgery.
As the nurses and midwives of Nonnatus House prepare to celebrate Sister Monica Joan's birthday, they face an influx of new patients when a nearby maternity home suddenly closes, leaving many expectant mothers in urgent need of support. Lucille treats a woman whose father has a long-hidden secret he feels he cannot hide any longer, while Tom and Nurse Crane struggle to move forward with their lives.
As spring arrives, Nonnatus House welcomes two new nuns, the experienced Sister Hilda and newly qualified Sister Frances, who must acclimatise to the changing East End. A complicated multiple birth tests the skills of some of the midwives to the limit, but Trixie has to face her fears and Valerie deals with a shocking case that arrives unexpectedly.
Lucille treats an elderly hoarder (Annette Crosbie) suffering from a malodorous leg ulcer, and fears that living surrounded by towering piles of rubbish, books and tins of food will have a serious effect on her recovery. Sister Hilda has a challenging case on her hands when a family newly arrived from Ghana are found to be suffering from an unidentified illness, and Violet runs for a place on the local council, but Fred is not convinced she can make a difference to the community, placing more faith in the Civil Defence Corps.
Valerie helps a mother of five come to terms with her latest child's birth defect. The Turners oversee a measles vaccination trial at the clinic, but are concerned by an overly anxious first-time mother. They soon discover she is concealing a devastating loss, which could have serious repercussions. Nurse Crane decides to bring a taste of the seaside to Poplar for the Whitsun bank holiday, and Violet's political career goes from strength to strength as she wins the seat on the council for Poplar North.
Sister Julienne is drawn into a conflict between an estranged mother and daughter, both of whom are pregnant. Nurse Crane visits a photographic gallery in Soho with Sgt Woolf, but the trip does not go to plan, and Sister Frances' shyness causes concern. Trixie's keep fit class is chosen to host a special event, but her star pupil is devastated to learn that she is pregnant.
Mother Mildred returns to Nonnatus while Nurse Crane is in hospital receiving treatment for her back. With help from Trixie, she provides care for a retired dock worker whose former job has taken its toll on his health, only to discover his son may be suffering from a more severe condition. However, her insensitive manner angers the family and they refuse to let her help them.
Sister Frances panics when Mother Mildred insists that she attend her first solo birth before Nurse Crane returns, and Trixie treats a pregnant woman who discovers that she has gonorrhoea, a condition that could have serious implications for the health of her baby. The Turners try to persuade Violet to approve the formation of a Brook Advisory Centre, and Lucille looks forward to a second date with Cyril.
Shelagh organises a ballroom dance to raise money for the maternity home, in the hope of taking her mind off May's impending adoption. A terminally ill patient laments that she will not get the chance to dance one last time, but Sister Hilda is determined to make sure she does. Fred suffers an embarrassing condition, and cannot bring himself to see Dr Turner, while Nurse Crane is discharged from hospital and tries to play matchmaker between Sgt Woolf and Miss Higgins. Valerie and Trixie are called to testify in a court case. Last in the series.
Mother Mildred declares that God is calling her to set up a branch house in the Outer Hebrides, so she is joined by several other members of the team, including Dr Turner, Shelagh, Mother Mildred, Trixie, Sister Julienne, Valerie, Lucille and Fred, many of whom have been struck down by flu and like the idea of convalescing in the fresh Scottish air. However, as they set about establishing an antenatal clinic and treating the local population, they must battle not only the weather and challenging terrain, but the suspicions of the islanders. Back in Poplar, Reggie is inspired to attempt a world record.
A woman is caught stealing milk from Nonnatus House, but she pleads for mercy from sisters Julienne and Monica Joan, explaining that she has been stealing milk as she is pregnant. As Sister Julienne learns more about her, she is convinced that this woman needs help becoming the mother she wants to be. Meanwhile, Dr Turner puzzles over a mysterious string of symptoms, and the blossoming romance between Miss Higgins and Sgt Woolf is thrown into jeopardy.
Lucille is seconded to St Cuthbert's when a ward sister is off sick, but a lift malfunction sees her spend the evening with mother-to- be Connie instead of her planned rendezvous with Cyril. Nurse Crane tries to help a woman who is newly arrived from East Pakistan, while Shelagh enlists Violet, Trixie, Sister Frances and Valerie to put on a charity fashion show to raise money for the incubator fund.
Sister Julienne volunteers to put up four trainee doctors at Nonnatus House while they undertake the practical aspect of their obstetrics diploma, hoping the exercise will remind the council how vital the home is to the community and help remove the threat of demolition. There is a lot of excitement about the new arrivals and the doctors don't disappoint. On his CDC rounds, Fred comes across a street marked for demolition, with one house clearly showing signs of life.
Sister Frances is at a loss when she cares for diabetic and recovering cancer patient Albert Calthorpe whose fiercely independent wife Grace refuses to accept further help, despite caring for her husband, her elderly mother and her pregnant daughter. Meanwhile, Violet is given two tickets to new hit film The Sound of Music and decides to raffle them off with all proceeds going to the incubator fund, while Timothy, Angela and May want to give their parents a night off, but they're not sure how.
At the Turners, Shelagh receives a phone call from the Hong Kong adoption agency, which has the alarming news that someone from May's past has arrived in the UK and wants to see the little girl. Meanwhile, Valerie's cousin Maureen is heavily pregnant and hoping her baby will be born on Thursday, the same date as her father and grandfather. However, her due date isn't so soon and keen to bring on the birth, Maureen takes a big risk by secretly taking castor oil - with potentially disastrous consequences.
Sister Julienne decides it is time to take matters in hand when a letter arrives from the council saying that it will cut funding to Nonnatus House and no longer pay for the accommodation, and goes to see Violet at one of her open sessions as a local councillor. At clinic, Nurse Crane meets and cares for heavily pregnant Bonnie, who is not married but committed to the baby's father Eddie, while Kevin's dependency on pain relief is discovered by the team and Dr Turner and Miss Higgins must find a way to help him.
Having dealt with some extremely naughty sheep last year in the Outer Hebrides, this year the gang are in Poplar. Everyone is hoping for a nice uneventful Christmas, but of course that doesn’t happen! Sister Monica Joan is rushed to hospital, while Trixie is less than impressed to receive a subscription to a Marriage Bureau as a Christmas present. Meanwhile, the circus is in town as ex Time Lord Peter Davison plays Mr Percival the Ringmaster.
Everyone is looking forward to Trixie and Matthew's wedding and a bonny baby competition brings the community together. It's not all good news, however, as the team learn about a pregnant woman and her family living in a cramped caravan, while a worrying disease outbreak directly impacts the residents of Nonnatus House.
Nonnatus House is abuzz with excitement as the countdown to Trixie and Matthew’s wedding begins. Whilst Sister Veronica has appointed herself in charge of organising the wedding gifts, Trixie’s brother, Geoffrey Franklin, arrives from Malta and immediately starts arranging the perfect hen do. However, the approaching nuptials cause stress levels to escalate as a catalogue of small and great disasters threaten to spoil the day. Dr Turner, Shelagh and Timothy are first on the scene of a fatal car crash. Dr Turner experiences the biggest test of his career as they race against time to save a precious life. Meanwhile, Nancy considers her future, and Sister Julienne hatches a plan to save Nonnatus House once and for all.