Murtaugh delves deep into the psyche of a former navy seal who is wanted for criminal activity, and draws parallels between him and his partner, Riggs, who also served in the military. Riggs' connection to the suspect threatens to interfere with the case, but it also forces him to open up to Murtaugh.
When Riggs and Murtaugh investigate a high-profile case surrounding the murder of a young model, they uncover a vicious secret behind the locked mansion gates of one of LA's wealthiest families. Riggs gets a jolt from his past when he discovers that an old friend of his wife has ties to the case. Murtaugh is shocked to hear that his daughter is sending promiscuous photos to her new boyfriend.
When a million dollar casino heist takes a deadly turn, Riggs befriends the only credible witness, an eight-year-old boy, and takes him into his care. Murtaugh pulls some dangerous stunts in an attempt to prove to everyone that he can be a motorcycle guy. Riggs contemplates what to do with the money he received from selling his home in Texas.
The whole precinct's holiday celebrations are cut short when they're called to examine a ruthless homicide linked to Eddie Flores (guest star Raul Casso), the deranged nephew of a notable drug lord who has a previous history with Riggs. The holiday season weighs heavily on Riggs, who flashes back to past Christmases with his former wife, Miranda. Murtaugh is also a little preoccupied with his neighbor's obnoxious holiday decorations.
When a car containing massive amounts of cocaine is stolen from an impound lot, Riggs and Murtaugh become embroiled in a notorious car theft ring. Meanwhile, Murtaugh experiences some frightening chest pains. If Riggs' driving isn't enough of a trigger, the lead defense attorney on the case is none other than the terrifyingly brilliant Trish Murtaug.
A brutal car crash reveals that Cahill is the target of a murderous stalker, causing Riggs and Murtaugh to turn the tables and start asking her questions for a change. Meanwhile, after finding Murtaugh's file in Cahill's office, Riggs becomes obsessed with finding out about his past as Roger and Trish reel over their daughter's newfound fake ID.
Riggs and Murtaugh are forced to work with DEA agent Karen Palmer again, to protect Leo Getz, an ambulance-chasing attorney who was linked to the Cartel. As the three delve further into the case, they begin to realize that Leo may not be the only one with a target on his back. In the meantime, Riggs begins to view Agent Palmer in a new light while Murtaugh is left worried after Trish makes a spontaneous decision
Murtaugh follows Riggs down to Mexico, where he plans to avenge his wife's death and finish off Tito Flores once and for all. Once back in the States, they have a few people to answer to during the ongoing investigation around Flores, including Murtaugh's family. Meanwhile, Avery is questioned by Internal Affairs about the integrity of his department.
Riggs and Murtaugh respond to the death of a plastic surgeon, drawing them into a case involving an illegal drug ring run out of a wellness clinic. Things heat up when Palmer from the DEA and Riggs compete to solve the case first. Meanwhile, Trish and Murtaugh face the emotional challenges of sending their first son, RJ, off to college
Murtaugh and Riggs investigate the mysterious death of famous singer Shaye's bodyguard. Murtaugh turns to his daughter, a fan of the singer, to learn more about Shaye's background and uncover the possible suspects. Meanwhile, Riggs learns the responsibilities that come with being in a relationship with help from Murtaugh.
Murtaugh and Riggs respond to the murder of an escaped patient of Dr. Cahill's who mysteriously goes off the rails. The investigation brings to light a hidden scheme far bigger than they imagined. Meanwhile, Riggs' anger gets the better of him once again, causing Avery to consider whether or not he is fit to serve. Also, family tension runs high between Murtaugh and Trish, who have to make big decisions about R.J.
When Detective Bailey's sister, Jess, runs into trouble with the law, Bailey must decide how far she's willing to go to protect her family. Meanwhile, with Trish away on a company retreat, Murtaugh is left to help Riana navigate boy problems, and Riggs deals with the fallout of a night of heavy drinking.
After the fatal end to an argument on a construction site, the squad works to untangle facts about the incident. Meanwhile, Riggs struggles to rekindle his relationship with Molly, Trish's job is on the line as she tries to close a big deal at work, and Murtaugh gets one last chance to make it right at home.
The duo sets out to unlock a case about a veteran hitman who Murtaugh has followed for years. Meanwhile, Riggs struggles to find a connection with his father, Murtaugh scares Riana with his overprotective driving lessons, and the team finds themselves wedged in a dangerous incident that tests their trust.
The squad is on high alert after an apparent threat is made on Riggs' life. With Murtaugh taking on more responsibility at work, he and Riggs have to deal with their changing relationship. Meanwhile, Trish gets caught up in some trouble and Molly asks Riggs to make a big decision about their future.
Cole reflects upon his time working for the CIA, as a person from the past makes a startling reappearance. Murtaugh struggles with his own mistakes, after a murder raises questions about a suspect he put away years prior. Meanwhile, Leo Getz returns as the attorney on the case and tries to convince Trish to join his team.
While Cole gets into the holiday spirit for his first Christmas with Maya, Murtaugh hopes he can convince RJ to come back home from Costa Rica for the holidays. At the precinct, Cole and Murtaugh are saddled with a complicated burglary and home invasion case. Meanwhile, Avery's holidays are a bit blue, and Bailey is still trying to figure out her new partner.
Cole finds himself on the rebound after Natalie's engagement, and his new romantic interest, Julie, has an unexpected connection to A.D.A. Erica, complicating things at work. Meanwhile, Murtaugh worries about the connection between the murder he's investigating and a new opportunity for Trish to serve as co-counsel on a high-profile lawsuit with Leo Getz.
Murtaugh takes a family vacation, but is pulled back into work when he witnesses an alleged abduction. Cole is left to investigate a murder himself, but the two cases begin to intersect. Meanwhile, Erica's mother, Senator Malick, comes to town and stirs things up between Erica, Cole and the case at hand.
Murtaugh and Cole investigate the murder of an underground MMA fighter when Murtaugh realizes his fighting moves aren't as sharp as they once were. Meanwhile, Trish is unfulfilled by her practice and considers running for a public office. Also, Cole and Erica try to keep things casual and uncomplicated but their plan backfires when Maya reacts to her family changes in a negative way.
When Cole and Murtaugh investigate a case involving a father and daughter crossing the Mexican border, they end up uncovering a major issue with California Boarder Patrol. Meanwhile, Trish prepares her campaign for D.A. and must face parts of her past, before they find their way into the media spotlight. Cole also confronts his past when he experiences flashbacks as a result of an injury.