The Great Pussini, opera star, comes into town and immediately takes to Sonja, winning her affection. Meanwhile, Heathcliff is furious and tries to show Sonja that Pussini is a fake. The voice of Pussini is really a little nerd cat. Sonja ends up leaving with him. Heathcliff is embarrassed and puzzled. The jealous Heathcliff exposes Pussini as a fraud and turns his concert into a fiasco.
After returning from the beach, Hector, Wordsworth and Mongo discover that their Cadillac has been stolen. Riff Raff figures that a day at the circus will help them take their minds off their loss. But they soon realize that their car is being used by the circus as part of the show. Now they must devise a plan to get it back.
Heathcliff and Iggy go to visit the zoo so that Heathcliff can finally meet the king of the beasts, the lion. But to Heathcliff's dismay, the lion is a kind-hearted and gentle creature and not at all to Heathcliff's liking. The apes in the zoo make fun of the lion because he is so tame. Heathcliff gives the cowardly lion some pointers on being fierce and strong which helps the lion put those nasty apes in their place!
Spike's cousin, Bull, is a ferocious looking guard dog who sports a bone out of his mouth the way a tough guy might use a cigar. He convinces Spike that he no longer should take guff from Heathcliff and proceeds to teach him to defend himself but to no avail. After Bull has harassed everyone in the neighborhood, he challenges Heathcliff to a fight in the vacant lot on Elm Street and guess who wins? Who else, Heathcliff!
Heathcliff hears Iggy saying how wonderful it is to have a pet, and decides he should have a pet too. He tries out Spike and Mungo, but they do not make good pets at all. He frees a live lobster from the fish store which makes a great pet until the lobster begs to go home to the ocean and Heathcliff generously complies.
Wordsworth is convinced he has a rare cat disease which Riff Raff read about in the paper, so the gang take him to a cat witch-doctor who tells them the only cure is an alligator hair. The cats risk their lives in a swamp before returning to tell the doc that alligators don't have hair. No matter, Wordsworth seems better.
During an afternoon of deep-sea fishing, Heathcliff and the Nutmegs land their boat on a small island for a picnic and soon learn the island is inhabited by a tribe of wild cats called Meow Meows. These savages capture the Nutmegs, but Heathcliff cleverly rescues them from being sacrificed in a native ritual.
When Heathcliff tries to follow Iggy to a Boy Scout camp, the scout master forbids it, saying, "A common house cat could never survive in the wild." This infuriates Iggy's pet, who sneaks along anyway just to prove the scout master wrong. Even though Heathcliff gets into all kinds of mischief in the wilderness, he leads the group to safety when they get lost in the woods, so he becomes the first cat ever to be named "Scout of the Year!"
After discovering several empty cat food cans in the Nutmeg pantry, Heathcliff decides to go to the cat food cannery to complain. There he defeats a vicious guard dog in battle, and manages to get himself appointed cannery guard by the foreman! The new station is short-lived, however, when what begins as a picnic with the Catillac Cats in the factory turns into a free-for-all, and the old guard dog returns to seek his revenge.
Iggy and Marcy take Heathcliff along shopping for an anniversary gift for Grandma and Grandpa Nutmeg. Heathcliff seizes every opportunity to cause mayhem in the department store, and even tries to swipe a rhinestone collar for Sonja to replace the one she's recently lost. On the way home, Heathcliff finds Sonja's lost collar in the grass, which makes him a hero.
Heathcliff sneaks into the Van Corkingdale mansion to challenge Bruno, their ferocious guard dog, and determine who the real king of the neighborhood is. Inside, Heathcliff defeats Bruno, allowing burglars to raid the house! Later, when the some crooks attempt to burgle the Nutmeg home, Heathcliff traps them for the police, and returns all the previously stolen goods to the mansion.
Cousin Lucky comes to visit Riff Raff seeking help. It seems everywhere he goes, disaster follows, and his reputation as a jinx is so widespread, everyone runs when they see him coming. Riff Raff gives Lucky a good luck charm, and it really seems to work! However, Lucky becomes overconfident, discards the charm, and once again it rains only on him wherever he goes.
Heathcliff learns that playing Momma Cat is no easy task after he is adopted by a tiny kitten lost from her mother. Heathcliff teaches the little girl all about life as they roam the streets together in search of the missing mom, and they soon become fast friends. Heathcliff's big responsibility ends when at last the mother and kitten are reunited, but a touching moment at the end reveals that Heathcliff is really going to miss the little thing.
When the local fishing bureau announces a shortage of fish in the area, the Catillac Cats turns to Professor Flixx for help. With the aid of the professor's latest invention, a Flixx fish trumpet that will summon fish at a single note, the cats get their fill. But not before an overly-zealous Hector learns a valuable lesson about greed and friendship.
When the local policeman warns Heathcliff that any more of his pranks will land him in jail for life, our little monster decides he'd better reform. And when a new cat gang moves into town to terrorize the neighborhood, Heathcliff is forced to stand passively by and let them take over his territory. But it isn't long before the policeman is back knocking on Heathcliff's door; only this time he's come to ask Heathcliff's help. Heathcliff can do anything he wants, just as long as he runs those nasty new cats out of Westfinster! Things return to normal in no time as Heathcliff shows the punks who's really the boss!
A big, muscle-bound cat named Pecs tries to take Sonja away from Heathcliff, so he starts working out in order to beat Pecs at his own weightlifting game. Unfortunately, the manager of the gym is in cahoots with Pecs, and throws Heathcliff every possible curve. Heathcliff catches on, and throws the curves right back. Sonja is his in the end.
Riff Raff and the Catillac Cats go camping in the woods and meet Big Foot who threatens their camp. They try to catch him for fame and fortune. In the end Big Foot gets away, but upon overhearing the boys tell their disappointment over their loss of fame, Big Foot comes out of the woods and auditions for them.
Marcy gets a new cat, Tammy, who challenges Heathcliff's position as top cat in the neighborhood. It's a terrible blow to Heathcliff's ego to have a female cat take over, but neither he nor the alley cats can defeat this lady. Sonja knows how to handle Tammy, however, and puts Heathcliff back in charge.
Mungo's in love with a cute little cat named Dixie and everything is perfect. All except for one thing Dixie's older brother, Jake. Jake has conditions to prove Mungo is worthy of his little sister which include an athletic competition in which Mungo pole vaults, shot puts, runs the high hurdles, and performs other amazing feats all for the sake of a date with Dixie. Mungo's buddies pitch in to help Mungo win, but in the end it is Dixie who has the final say, and she wants Mungo - win or lose!
Heathcliff and Sonja go to the circus to see Heathcliff's cousin, Rollo the cat-clown. Rollo is troubled because the wild circus animals have become tame, the trapeze artists are afraid of heights, etc. Our hero discovers a plot by a rival circus, and with the help of the Catillac Cats, he fails the evil plan.
Sonja tells Heathcliff he needs to lose a little weight, so he goes on to crash diet with the help of the Alley Cats. Every time Heathcliff weakens and tries to eat something, Mungo or Hector snatch the food away. When Heathcliff is finally able to tell Sonja he has lost ten pounds, she admits he'll love him at any weight, so our hero instantly returns to his former gluttonous ways.
Heathcliff suffers a nasty bang on the head, which renders the "Devil Cat" side of his personality stunned and permits the "Angel Cat" side to take over. Suddenly Heathcliff is good as gold and begins performing numerous acts of kindness toward Spike. Spike is confused, but certainly willing to take advantage of the situation. He even puts on a show for the other animals to demonstrate his new ability to make Heathcliff do his bidding. However, when the "Devil Cat" recovers, Heathcliff puts Spike back in his place posthaste.
Riff Raff must survive one night in a haunted mansion to win a contest of bravery for Cleo's affections. The Catillac Cats accompany Riff Raff, and are terrorized by all manner of embodied spirits. In the end, however, Riff Raff manages to employ the spooks to frighten away the competition for his love.
Hector, Wordsworth and Mungo decide to teach Heathcliff a lesson after a typical day of being picked on. That night when Heathcliff is fast asleep, the cats sneak into his house, and with Hector dressed like a ghost, frighten Heathcliff into promising to be nice to his friends. After a few days of being good, Heathcliff finally catches on and puts his sneaky friends back in their place.
It's Heathcliff's birthday, and he's a very happy cat. That is, until he realizes all his friends have forgotten! Everywhere he goes, cats and people blithely tell him they're busy, and send him away. Angry and hurt, Heathcliff decides to run away. When he goes into the Nutmeg home to get his things, everyone is there yelling, "SURPRISE!"
A lady moves into the neighborhood that has twelve gorgeous female cats. Riff Raff, Hector and Mungo try several plans to break into the house and meet the new felines, but only Riff Raff succeeds. However, once inside, he discovers that a harem is more than he had bargained for, and makes his escape.
When the Catfather and his mob move into the neighborhood, a naive Heathcliff accepts his offer to work for him, and unsuspectingly collects "gifts" from all the frightened animals in town. When he discovers from Sonja who he is really working for, Heathcliff, needless to say, takes care of things properly.
Mungo finds half of a treasure map in the junkyard, and the Catillac Cats take off for the desert to search for the lost booty. There they run into Pecos, a cat prospector who just happens to have the other half of the map. It's a mad rush to get to the treasure first, but there's plenty of loot for all.
Marcy dresses Heathcliff in baby clothes and is pushing him down the street, when two crooks disguised as mother and child rob a jewellery store. The police confuse the duos and throw Heathcliff in jail! Undaunted, our courageous cat escapes his cell, apprehends the true offenders, and surfaces a hero.
Much to Riff Raff's dismay, his mother is coming to town to see the beautiful mansion he lives in. Riff Raff, in a frantic attempt to cover up his fib, disguises his friends as servants and sneaks into a fancy house when the real owners leave, but Riff Raff's plan backfires and his mother finds out the truth. However, she doesn't mind at all that he is a simple alley cat and not the wealthy son she had thought.
Spike's mother is coming to visit, so he pleads with Heathcliff to let it appear that he runs things around the neighborhood. Spike says he'd be a disgrace to his family if they knew he was second to a cat. Heathcliff refuses on the grounds that he doesn't want his neighborhood misrepresented, and continues to torment Spike at every opportunity. However, Heathcliff quickly learns that he is no match for Spike's mother.
Heathcliff and Sonja land the leading roles in a movie which is filming in her town. However, once on the set, Heathcliff discovers he is merely a stunt double for a temperamental star. After surviving several rigorous stunts, Heathcliff challenges the conceited star, who storms off the picture, leaving Heathcliff to do the final love scene with Sonja.
The Nutmeg travel to New York for a vacation. Grandpa spins a yarn about how it's rumored there are alligators living in the sewer system and whoever could capture one would be a hero. While visiting a museum, Grandpa leaves Heathcliff with the hatcheck girl...but not for long. Heathcliff soon escapes and before long he's down in the sewers beneath the Big Apple, searching for an alligator. When he actually runs into one the episode turns into a wild chase in the sewers as cat and reptile clash in a titanic battle.