Three years into the zombie apocalypse, a ragtag team of everyday heroes comes together to transport the only known survivor of the zombie virus from Upstate New York to a lab in California, in hopes of using his blood for a vaccine. A zombie baby proves to be an early obstacle, and what they don't know is that their last, best hope for a vaccine is hiding a dark secret that threatens them all.
On the road to find Lucy in Illinois, Doc and Addy are forced off the road by a retro presidential limo. Turns out Sketchy is running for "President of the Apocalypse" with Skeezy as his campaign manager. Doc and Addy follow them to Wall Drug, South Dakota and witness the somehow lucrative, always entertaining train wreck that is Sketchy and Skeezy.
Warren's Apocalyptic Dream of a Black Rainbow sends our heroes on a mysterious new mission to save the Apocalypse from something even worse. Warren awakens from a Coma to find herself in ZONA two years later, with Murphy seemingly cured, and the rest of our heroes either dead or fighting for their lives against unkillable "MAD-Z's" caused by an evolving Zombie Virus.