Charlie has to make dinner for Lola, but she's a very picky eater and refuses to eat carrots, peas, mashed potatoes, fish sticks and her least favourite food, tomatoes (although she has never tried these foods before). So Charlie tricks Lola into eating the foods she "hates" by changing their names: Carrots to "Orange Twiglets from Outer Space", Peas to "Green Drops from Green Land", Mashed Potatoes to "Cloud Fluff", and Fish Sticks to "Ocean Nibbles from under the sea".
Lola likes dogs, but can't have one because her parents insist that she must be responsible enough to have one. Her and Lotta's favourite dog is Marv's dog Sizzles. At the park, the girls persuade Marv to leave Sizzles under their care while he and Charlie go play football. However, when they finally get their wish, Lola and Lotta detach Sizzles from his leash (despite Marv telling them never to do so) while fighting over who's in charge, and he goes missing by accident. When the girls finally find the dog, they also see one that looks just like him, and can't tell them apart. They chose the one that sits first (Sizzles' best trick) but aren't satisfied with their pick. Fortunately, Charlie reads the dog's name tag, confirming that he is Sizzles.
Lola has a loose tooth, but does not want it to fall out, until she learns about the tooth fairy, who will leave her money in exchange for her tooth. But then the tooth refuses to come out; when it finally does, Lola stores the tooth for the tooth fairy, but soon, she loses the tooth for real. Eventually, she and Charlie find the tooth.
Lola finds a spider in the sink when trying to brush her teeth, and she doesn't like spiders very much. Charlie tries to show her that some spiders don't hurt us and that they're our friends. Soon, Lola has grown attached to the little creepy crawly, now keeping him as a pet and naming him Sidney. After they have place the spider outside, the weather changes, and Lola worries on what might happen to her new little friend.
Lola is going to stay at Lotta's house for the night, and packs everything she needs for them to play Cinderella. Back home, Charlie and Marv set up their race car track. But Lola arrives without her suitcase and Charlie and Marv can't find an important piece of the track, teaching both parties a lesson in improvisation and imagination.
Charlie and Marv are to appear in a musical assembly about outer space at school. Lola wants to join in and desperately wishes that she could play music too, but can't seem to master any instruments. Charlie comes up with some makeshift instruments that she might be able to manage. But on the day of the presentation, Marv is sick - who will take his place?
Granny and Grandpa are taking Charlie and Lola to the zoo. But Lola eats all of her sandwiches before lunch, wastes all her bread to feed to the ducks, uses up all of her camera film, and spends all of her money – when she is set on buying a toy seal for the bath. Charlie reluctantly helps her out, but wants her to learn to save things.
Lola is very superstitious and gullible. She hops to bed so some "living sea plants" won't tickle her, sleeps tightly so the bed bugs won't bite, washes really hard behind her ears so mushrooms won't grow there, and turns around three times when she sees a magpie. Charlie quickly regrets it when he tells her not to step on the cracks in the pavement, or else the bears, crocodiles and lions that live underneath will get her.
Lola is very excited for Christmas, but her Christmas is about to be ruined when she mixes Lotta's card for Father Christmas' by accident. When Lola and Charlie find that the door for Christmas on their advent calendar has been lost, they make their own door on the calendar, making their way to the magic elves at the North Pole.
Lola is refusing to go to the optician until she sees her classmate Minnie with beautiful glasses. When she goes to the optician, she finds out that she does not require glasses. At home, Charlie helps Lola make her own glasses. At school the next day, Lola, Lotta, and Minnie are wearing their own glasses and are happy.
On a hot day, Charlie and Lola decide to go outside to be joined later by Arnold Wolf. When Arnold spills Lola's fresh ice cream and refuses to share some of his ice cream, Lola becomes furious at Arnold and decides to not be friends with him anymore. Charlie tries his best to try and get Lola to like Arnold again.
When Lola takes her old tricycle to the park, she discovers her best friend, Lotta, has got a new bicycle with training wheels from her cousin. Lola struggles to keep up on the tricycle, and wants a proper bicycle. Charlie decides to give his old bicycle to Lola, who learns how to ride it with the training wheels. The next day, Lotta rides the new bike again, but without the training wheels. Lola feels like she should ride her bike without the wheels as well, but realizes that it is much harder.
When Charlie and Lola go to the beach by their grandparents' house, they begin their tradition of building a sand castle. However, a girl named Clem becomes curious about the summer's castle. Clem examines Lola's shells, takes Lola's spade, erratically places seashells on the castle, and accidentally falls on the castle.
Charlie and Lola just received a new puppet stage to build. When Charlie tries to read the assembly instructions, Lola doesn't pay attention and constructs the stage incorrectly. Throughout the day, Lola discovers her inability to listen to instructions. She forgets her umbrella, gets her elephant puppet all wet, spills water, and more.
While Charlie and Marv play a game called "Squidbones", Lola thinks it sounds like arguing, and is convinced that Charlie and Marv are not friends anymore. Later, after writing a letter that says "From Charlie", Charlie explains that he was just playing "Squidbones" with Marv, and they weren't arguing after all.
It is the beginning of Autumn term at school, and Lola finds that everything is different. She and Lotta have new sitting places, she has a new teacher, the school smells funny, and the leaves have fallen off of her favourite tree. Meanwhile, Charlie and Marv create a time capsule for the Autumn Fair.