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Atypical

2017
as Elsa Gardner

The Woman in the Window

2021
as Jane Russell 2

Fargo

2014
as Lorraine

Awake

2021
as Dr. Murphy

Good Time

2017
as Corey Ellman

Hunters (2020)

2020
as Chava Apfelbaum

The Hateful Eight

2015
as Daisy Domergue

Annihilation

2018
as Dr. Ventress

Kill Your Darlings

2013
as Naomi Ginsberg

The Spectacular Now

2013
as Sara Keely

Patrick Melrose

2018
as Eleanor Melrose

Lisey's Story

2021
as Darla Debusher

The Machinist

2004
as Stevie

Road to Perdition

2002
as Annie Sullivan

White Boy Rick

2018
as Alex Snyder

Kansas City

1996
as Blondie O'Hara

Childstar

2004
as Suzanne

The Jacket

2005
as Dr. Beth Lorenson

Backdraft

1991
as Jennifer Vaitkus

Eyes of a Stranger

1981
as Tracy Harris

LBJ

2017
as Lady Bird Johnson

Sister, Sister

1987
as Lucy Bonnard

In the Cut

2003
as Pauline

Grandview, U.S.A.

1984
as Candy Webster

Easy Money

1983
as Allison Capuletti

The Men's Club

1986
as Teensy

Wrong Is Right

1982
as Young Girl

Washington Square

1997
as Catherine Sloper

eXistenZ

1999
as Allegra Geller

The First Time

1982
as Bonnie Dillon

The Quickie

2001
as Lisa

Partners in Life

1990
as Blossom

Poolman

2024
as Susan

Angel City

1980
as Kristy Teeter

Bastard Out of Carolina

1996
as Anney Boatwright

Crossed Over

2002
as Karla Faye Tucker

Jake Squared

2014
as Sheryl

Flesh + Blood

1985
as Agnes

Welcome to Me

2014
as Deb Moseley

Rush

1991
as Kristen Cates

Open

2014
as Holly

The Big Picture

1989
as Lydia Johnson

Greenberg

2010
as Beth

Palindromes

2004
as 'Mark' Aviva

The Machinist ... Breaking the Rules

2005
as Jennifer Jason Leigh

Me

2014
as Kelly

The Anniversary Party

2001
as Sally Therrian

Buried Alive

1990
as joanna goodman

Georgia

1995
as Sadie Flood

A Thousand Acres

1997
as Caroline Cook

The Love Letter

1998
as Elizabeth Whitcomb

Skipped Parts

2000
as Lydia Callahan

The Hudsucker Proxy

1994
as Amy Archer

Rag Tale

2005
as Mary Josephine 'MJ' Morton

Miami Blues

1990
as Susie Waggoner

Under Cover

1987
as Tanille Laroux

Anomalisa

2015
as Lisa Hesselman (voice)

Morgan

2016
as Dr. Kathy Grieff

The Moment

2013
as Lee

Sharp Stick

2022
as Marilyn

Dolores Claiborne

1995
as Selena St. George

Single White Female

1992
as Hedra 'Hedy' Carlson

Sid & Judy

2019
as Narrator - Judy Garland

Short Cuts

1993
as Lois Kaiser

I Think I'm Having A Baby

1981
as Laurie Mcintyre

Crooked Hearts

1991
as Marriet Hoffman

Possessor

2020
as Girder

The Hitcher

1986
as Nash

Director

Movie The Anniversary Party 2001

Writer

Movie Greenberg 2010
Movie The Anniversary Party 2001

Producer

Movie Greenberg 2010
Movie The Anniversary Party 2001

Guest Star

Episode CBS Afternoon Playhouse
I Think I'm Having a Baby
1981
Episode Mission Hill
Kevin Finds Love (or Hot for Weirdie)
2002
Episode Hallmark Hall Of Fame
The Love Letter
1998
Episode Variety: Actors on Actors
Episode 3
2016
Episode Twin Peaks
Part 12
2017
Episode King of the Hill
I Remember Mono
1998
Episode The Rosie O'Donnell Show
Jennifer Jason Leigh, Greg Germann, Everything
1999
Episode Superman: The Animated Series
Absolute Power
1999
Episode Weeds
Machetes Up Top
2009
Episode Twin Peaks
Part 13
2017
Episode LA Times: The Envelope
Supporting Actresses
2016
Episode Twin Peaks
Part 15
2017
Episode The Late Late Show with James Corden
Von Miller, Jennifer Jason Leigh, Joe Manganiello, Glen Hansard
2016
Episode Late Show with David Letterman
Show #0122
1994
Episode Conan (2010)
Jennifer Jason Leigh, Andrea Savage, Benjamin Booker
2017
Episode Twin Peaks
Part 16
2017
Episode The Rosie O'Donnell Show
Vanessa Williams, Jennifer Jason Leigh, Jon Tenney
1997
Episode Twin Peaks
Part 9
2017
Episode Jimmy Kimmel Live!
Quentin Tarantino & the Cast of "The Hateful Eight", Rick Ross
2015
Episode Baretta
Open Season
1977
Episode Twin Peaks
Part 2
2017