Alice Klieg (Kristen Wiig), a mentally ill single woman living on disability benefits, and fan of Oprah Winfrey, wins the ''California Stack Sweepstakes'' lottery jackpot of $86 million. She appears on the local TV news celebrating her win, but is upset when the speech she had prepared is abruptly cut off after she mentions using masturbation as a sedative. She discontinues her medication, against the advice of her psychiatrist, Daryl Moffat (Tim Robbins), and moves into a casino hotel with her best friend Gina Selway (Linda Cardellini).
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