The murder of Bryan Mills' sister launches him into a dangerous mission for revenge against cartel boss Carlos Mejia. A secret US intelligence agency covertly uses Bryan as bait to capture Mejia, and recruits Bryan to become a part of their team.
Bryan gets his first chance in the field but the mission goes bust, resulting in a tragic death. The team uncovers a group of government officials skimming off of refugee funds, which also leads Christina to reconnect with a long lost love. Meanwhile, Asha shows up unexpectedly at Bryan's doorstep.
Bryan and team search for a suspected terrorist who has been taken, leading them to uncover a deeper plot within their own government. Christina receives troubling news and turns to Harry for support. Asha expresses her concern over Bryan's fixation with Mejia.
Riley's insistence to uncover the truth behind a fatal drug given to war vets results in her asset's child being taken. Bryan defies orders to rescue the girl and uncover the truth. When a break-in at Asha's apartment leaves her shaken, a new neighbor is there to calm her nerves.
Christina orders the retrieval of sensitive documents in Zurich needed to prevent economic and political disaster. But the mission to break into a bank vault turns into a three-way battle, and a race to escape safely. Meanwhile, Asha's trust in Elena proves to be misplaced and leaves Bryan vulnerable.
The ODNI are tasked with helping a Russian FSB agent defect, but the agent's pregnant girlfriend creates a problem for their plans. Meanwhile, Christina searches for a mole in the CIA and John faces a spiritual crisis after trying to resolve his brother's problem with a local gang.
Bryan is taken during the team's efforts to thwart a Mejia weapons operation; Bryan and Asha take the next step in their relationship.
The ODNI assist an Israeli spy with early onset Alzheimer's when her own agency tries to kill her. Also: Christina worries she may face a similar fate as she is threatened by forces within her own organization and Bryan and Asha have an argument due to Bryan's trust issues.
ODNI is forced to deliver a hostage to the FBI, but plans to hijack the transfer surface from the cartel. Later: John and Rem try to stall the handover; Bryan tries to keep the hostage in his custody; and Asha learns true identity of her best friend.
In the season finale, the FBI threatens to remove Christina from command and Bryan and John lead a rogue mission that risks everything to stop Mejia's associates before they cross the border.
Bryan Mills fights for his life inside a secret Mexican prison and plans a series of dangerous deals to put him on track for escape to the United States. But plans change when Mills and a young migrant girl are taken by human traffickers. Meanwhile, Christina Hart leverages her spycraft skills to obtain powerful new software that could locate Mills, and enlists two unlikely allies to aid in her mission to bring Mills home.
When a plane crashes carrying Bryan Mills and a key witness in a murder investigation, a wounded Mills must call upon the survival skills his father taught him to overcome the elements, find a way out of the woods and protect the witness from a lethal team of mercenaries on their tail. Meanwhile, Santana organizes a 'go big or go home' plan to locate the downed plane.
A laid-off worker kidnaps a high-powered accountant in revenge for his lost pension, and the team gets swept up in a case of class warfare when Bryan decides to help the kidnapper get justice.
When the President's emergency "football" is stolen, Bryan and the team must recover it before classified national security measures fall into dangerous hands.
Santana must face her past when a foreign diplomat linked to a sex trafficking ring is kidnapped.
When the wife of a war hero senator is taken, Bryan and the team must determine if her disappearance was orchestrated by a foreign government or someone closer to home. Meanwhile, Christina's meeting with an old friend brings up painful memories.
Bryan and Santana must extract a nuclear physicist long thought dead, from a secret North Korean prison compound. Kilroy faces a moral dilemma when Hart asks him to locate a criminal wanted by a foreign government.
(Switchman) Hart takes a solo mission to track down the mentor who betrayed her, and the team tries to locate her before it's too late.
(Truth Hurts) Hart must find a way to stop an exiled former journalist from leaking the names of government assets abroad before innocent lives are taken.
Bryan must stop an act of biological terrorism when invasive species are stolen from the Global Seed Bank in Norway.
When a bomb goes off in Washington D.C., the team suspects an innocent man is being framed for the crime. Meanwhile, Kilroy tracks down a notorious hacker.
When a dangerous weapons dealer smuggles his wares into New York City, Bryan teams up with the FBI in a race to stop him before he reaches the safety of international waters.
When a CIA analyst's son is kidnapped, the team gets help from an unlikely source - another kidnapping victim. Meanwhile, Hart discovers the sinister motive behind the abductions.
Bryan must protect his cousin when he's targeted by a powerful crime syndicate. Meanwhile, Kilroy becomes a victim of blackmail.
The daughter of a government official working overseas is taken, and an unexpected suspect derails Bryan's rescue operation.
With Hart in grave danger, the team must find their own way to stop Ramsey before his plan to assassinate a senator starts a war with international terrorists. Series Finale.
