Season 1

Beginning its tale in 19th century England, young aristocrat Jonathan Joestar finds himself locked in bitter rivalry with Dio Brando, a low-born boy who Jonathan's father took under his wing after the death of Dio's father. Discontent with his station in life, Dio's fathomless lust to reign over all eventually leads him to seek the supernatural powers of an ancient Aztec stone mask in the Joestar's possession—an artifact that will forever change the destiny of Dio and Jonathan for generations to come. Fifty years later, in 1938 New York City, Jonathan's grandson Joseph Joestar must take up his grandfather's mission and master the abilities necessary to destroy the stone mask and its immensely powerful creators who threaten humanity's very existence, the Pillar Men.

La prima stagione dell'anime Le bizzarre avventure di JoJo ripercorre i primi due archi narrativi del manga originario: in Phantom Blood viene mostrato lo scontro tra Jonathan Joestar e suo fratello adottivo Dio Brando nell'Inghilterra di fine Ottocento; in Battle Tendency la lotta tra Joseph Joestar e gli Uomini del pilastro tra Stati Uniti, Messico, Italia e Svizzera nel 1938.

A relação antagônica de Jonathan Joestar e o irmão adotivo Dio dá início a uma linhagem bizarra, que continua com seu neto Joseph.

В каждом поколении славной семьи Джостаров находится прямой или побочный отпрыск, чье имя начинается с того же слога и, соответственно, потомок получает традиционное прозвище ДжоДжо. Начиная с бурного XIX века, удел каждого героя с таким прозвищем – борьба за выживание человечества против вампиров, зомби и прочих Джеков Потрошителей.

第一部「幻影之血」初代JOJO（乔纳森·乔斯达）的父亲收留了其“救命恩人”的儿子，一个名叫迪奥·布兰度的孤儿，抚养他成人， 但迪奥图谋JOJO家族的财产，谋杀了乔纳森的父亲。事败之后，为了报复，不惜戴上神秘的石鬼面具，成为了不老不死的吸血鬼，得到了不可思议的强大力量。而乔纳森后来也跟威尔·A·谢皮利学习了能杀死吸血鬼的波纹气功。他的青春是与迪奥一起的青春，而乔纳森在结尾要为这段青春画上句号！ 第二部「战斗潮流」在二十世纪三、四十年代的纽约，乔纳森乔斯达的孙子乔瑟夫·乔斯达，又遇上了新的敌人：超级史前生物柱之男。柱之男是创造吸血鬼的元凶，他们创造石鬼面的目的是为了获得更加强大的力量，但是因为缺少一样关键的物品，戴上石鬼面只能变成被他们当成食物的吸血鬼。为了自己的先祖（乔瑟夫·乔斯达的祖父乔纳森·乔斯达，以及父亲乔治·乔斯达，凯撒·安东尼·谢皮利的祖父威尔·A·谢皮利，父亲马利奥·谢皮利），两人寻找莉莎莉莎进行波纹气功的特训，这是能对抗柱之男的武器。为了保护自己所重视的一切，乔瑟夫和西撒与柱之男们展开了战斗。