The super-strong but slow-witted and pretty much insane superhero called ""The Tick"" is assigned to defend ""The City"". Arriving there, he meets Arthur, a bank accountant who got fired for wearing his moth suit (that everyone mistakes for a bunny costume). The Tick asks Arthur to become his sidekick and reside in their headquarters: Arthur's apartment. Some criminals calling themselves ""The Idea Men"", guys who don't want to work anymore and are impossible to understand because of their full-face masks, rob a bank. They fail, thanks to the Tick, but manage to escape. They proceed to threaten to blow up the City's bank if they don't get a million bucks, so the Tick and Arthur go out once more to stop their evil ways.
The Tick, American Maid, and Arthur go undercover as caterers to infiltrate Chairface Chippendale's party. Chippendale has gathered the City's criminal underworld to witness his latest scheme - employing Professor Chromedome to inscribe Chairface's name on the Moon! The Tick blows their cover but the trio escapes Chippendale's death trap and manages to stop him before he can carve more than the first three letters of his name on the Moon.
The Tick and Arthur go on a trip to a field park about dinosaurs. There they meet Dinosaur Neil, a scientist who shows the two that he has a real dinosaur cell, but it would grow if it isn't kept in a special substance. Neil accidently eats the cell and slowly turns into a half-man, half-dinosaur monster. Arthur realizes the ""special"" substance was merely aspirin, so he gets The Tick to feed a giant aspirin to the man-beast, turning him back into a human. In the end, Neil starts talking to and dating Arthur's sister, Dot.
The Tick's mind is taken over by an evil mind controller, Mr. Mental. (Yes, the Tick actually does have a mind). Mr. Mental uses the Tick to get a machine that will increase his mind abilities even more. It's up to Arthur and his other superhero friends to break the Tick out of Mr. Mental's control
The Breadmaster and his sidekick, Buttery Pat, plot to conquer The City by baking a giant Lemon Dessert Souffle and only The Tick and Arthur can stop him. The Tick uses the Human Cannon's cannon to fire himself, create a sonic boom, and collapse the Souffle before it can crush The City.
Flowers all around the City have come alive and are attacking the citizens. The criminal responsible is the evil Spanish sunflower El Seed, who wants revenge on humans and animals for mistreating flowers. When the Tick encounters him on his cropduster, El Seed sprays the Tick with a rapid plant-growth formula, causing flowers and plants to bloom all over his body. The Tick must get the antidote to save the City and himself, while fighing El Seed and his army of corn-soldiers. Fortunately he gets some help from the Civic-Minded Five.
The Tick and the gang take Arthur's sister's car to a Superhero night club. Arthur can't get in because he's a sidekick so he has to wait in the sidekicks lounge. A pseudo-superhero calling himself the Tick comes to the club and he and The Tick battle. Also a skinny, tiny villian called the ""Evil Midnight Bomber What Bombs at Midnight"" tries to blow up the superhero night spot, with hilarious consequences.
The Tick falls prey to an uncommon cold and is a less then subtle sufferer - Arthur while tending him goes next door and is kidnapped by Thrakkorzog, evil ruler of Dimension 14B. Thrak plans to conquer Earth with an army of Tick clones, but all that an Arthur-clone can get in the way of Tick's cell samples is mucus from his handkerchiefs. This leads to the creation of Mucus Tick, whom The Tick must battle for the sake of the world!
While shopping, the Tick and Arthur run afoul of Charles, aka Brainchild - a 9-year old with his brain in a transparent dome on his head. Assisted by his cyborg dog Skippy, Charles uses his multi-mega-destructor cannon to smash the Moon into the Earth, and only the Tick can save the day!
The government asks the Tick and Arthur to help when a space capsule with a monkey (with super smarts due to exposure with cosmic rays) crash lands in Pokoponesia - the heroes must recover the monkey. The two plus American Maid go there and find themselves in battle with the country's evil ruler, Pineapple Pokopo.
The Mole Men come to the surface on vacation and the Tick ends up being their tour guide and protector - they meet supermodel Mindy Moleford and pursue her romantically. Complicating matters is the arrival of the Lava Man, who tries to kill the Mole King.
The Tick gets knocked into space and into a self-exploratory journey by a giant genetically-enhanced clown. The remaining superheroes are forced to try to fight off the evil proto-clown until the Tick returns.
The Tick blows Arthur's bank account to upgrade his apartment into their secret headquarters - when Arthur doesn't take it well, Tick moves out and forms his own HQ - a rather shaky ""Crime Tower."" Hearing that the Tick is out of action, the 115-year old Terror summons his allies, Stalingrad, the Human Ton and Handy, Tuun-La, and the Man Eating Cow, and forms a new League of Evil to kidnap the mayor. Desperate, American Maid and the Arthur send forth the Tick Signal and the Tick realizes it is his destiny to be with Arthur and fight crime - the League is no match for the assembled heroes.
When Arthur goes off on a date with Carmalita on Hobby Night, Tick builds himself a new sidekick - Little Wooden Boy. Swiss Commandoes are after the notebook of Dr. Vahtoss, Carmalita's father and the inventor of Arthur's flight suit. And Blowhole, a giant long-distance running whale, accidentally swallows everyone, forcing the Tick to light up Little Wooden Boy to cause Blowhole to choke them up. Yep, just another day in The City...
The Tick is sent into space to blow the ""CHA"" out of the Moon from when Chairface tried to write his name in the moon. He blows the letter C up while he's inside it and gets sent through space. While in space he comes across a fantastically large alien named Omnipotus. The Tick befriends him and becomes a janitor on his body. But Omnipotus is an eater of planets and plans to eat the Earth when they get to it.
The Tick and Arthur run afoul of Venus, a portly but alluring love goddess/villain, and her sycophantic sidekick, Milo. The villains successfully remove The Tick and Arthur's arms and attach them to a pair of crude lookalike robots. Venus begins a crime spree with the help of the heroes' arms, while The Tick and Arthur evade a police manhunt and try to reclaim their errant extremities and save the day.
A flunky of air conditioner repair school makes a time machine and goes back and kidnaps the greatest inventors of all time so he can go back in time and reinvent everything.
The evil Brainchild returns and using his Nanny-of-the-Apocalypse, captures the Tick and transforms him into a two-headed bird that speaks bad French. Thus rendered powerless, The Tick is auctioned off by Brainchild, and it's up to the other heroes to sneak into the villain gathering and save him.
El Seed has returned and this time he wants to destroy the whole city by making a 400 year flower bloom in ""the bad way"". This flower will bloom in this ""bad way"", when there is no gentle music around. But when Professor Ichibana, owner of this rare & amazing flower, switches flowers with The Tick and Arthur, these accursed superheroes are tossed in El Seed's salad once again. El Seed creates Rosebud, who manages to steal the flower from Arthur. El Seed makes the flower bloom in ""the bad way"", but even he cannot control it's powers. Only the Tick's opera singing can save the City now...
A villain who can animate furniture and make it do her bidding falls in love with Die Fledermaus and tries to take over The City, with hilarious consequences and sexy results.
A camera crew follows the Tick and Arthur around for a day of crime fighting as they do battle with a unique villain.
Betty, Queen of the Ants, leads the ants of the City in revolt - it loses its major defender when the Tick is thoroughly creeped out and checks himself into Captain Sanity's Superhero Sanitarium. Betty and her minions capture the other heroes and lock them up in a giant People Farm, then collect enough glass to build a giant magnifying glass and use sunlight to fry them. Fortunately the Tick regains his (normal) sanity in the nick of time and saves the day.
A small-time bank robber in a stolen Santa Claus costume is chased into an electric billboard, gaining miraculous powers. He becomes Multiple Santa, a villain able to create electric clones of himself. The Tick, Arthur, and their superhero friends are called upon to rid The City of this Christmas menace.
An alien race called the ""Whats"" kidnap the Tick and Arthur to attempt to thwart their nemesis' the ""Heys"" from destroying the universe.
When Reno entertainers Soren and Frederica lose their prized animal, a trained dolphin, they call upon Arthur (they know his parents), and he and the Tick come to their aid. Little do they know that the dolphin, The Fin, plans to rule the world with his newly-invented Fish Magnet, with which he plans to bury the city in fish. The Tick must cope with his newfound weakness - gambling addiction - but manages to overcome it and beat The Fin by holding his breath longer.
The Terror sends his so-so villainous son Terry to recover his Desire-O-Vac - he lost it in an epic battle against the Decency Squad decades ago. The Tick is there listening to the old-time Squadders' tales and eventually gets involved, but it's a rebellious Terry and the aged Decency Squad members who save the day.
The Mustache, a U.S. secret weapon, escapes from the lab and tries to team up with its counterpart, the Russian Beard. In hot pursuit are Jim Rage and the Ladies of Project: Shave, so the Mustache takes refuge on the Tick's lip. Meanwhile, Dinosaur Neil and Dot plan for their marriage.
Dinosaur Neil, palaeontologist, curator of Dinosaur Grotto and one-time giant city-destroying mutant, is marrying Arthur's sister Dot. Chairface Chippendale, The Breadmaster and El Seed have other plans, though - plans which involve tampering with Neil's medication, man-eating bouquets, exploding wedding cake, and The Indigestible Man. And as if that wasn't enough, Neil's best man is... The Tick! It's up to our blue hero, Arthur and Dot to save Neil, with the aid of a submarine and 1,400 pounds of pungent raw meat...
The Deerfield Aztecs, a baseball team, crashed in Mexico and formed their own lost tribe of real Aztecs. They track their missing shortstop, Carmalita (Arthur's girlfriend) to America but grab Arthur instead. When the Tick and Carmalita pursue, the Aztecs and their leader Wally unleash ""Speak"", some kind of lowly animal that they intend to wed Arthur to. Tick takes a shine to ""Speak"" (as he names him) and he defeats the Aztecs and rescues Arthur.
Arthur is annoyed at his failed attempts to lose weight and dismayed at how much of a wimp he is. When he and Tick defeat a villain named Evil, Arthur takes Evil's strength-enhancing belt. When Arthur wears it, he gains confidence and likes seeing himself with a muscular physique. While dating Carmalita, Arthur picks a fight with two guys to show his new strength and confidence. The Tick is called in to end the fight and he tangles with Arthur. In the end, Arthur must get rid of his strength belt to save his and Tick's life. Arthur realizes the addiction the belt gave him and tosses it away so that he can be himself.
Mr. Mental steals a device from Dr. Pendecker that lets him hypnotize Arthur and the Tick into thinking he's a baby so they'll protect him. Unfortunately, Mental leaves the device in the taxi and has to recover it.
Sewer Urchin battles his arch enemy, the Sewer Czar, earning the respect of his fellow superheroes.
The Tick is chosen for a superhero exchange program - he travels to Antwerp while Eclair comes to The City. While the Tick and Eclair's sidekick Blitzen foil a kidnap plot against the King of Belgium, Arthur and the lightning-blasting Eclair must defeat the Breadmaster and his Gingerbread men.
The Tick and Arthur are invited to the Mad Scientist Fair to help Dr. Vahtoss try out his mind-transference device. Hilarity ensues when the two switch bodies. Chairface Chippendale moves in to try and steal the device and soon everyone is switching with everyone.
The Tick and Arthur end up in the distant past and uncover a diabolical plot by the Hotel Manager, a man from the future using prehistoric man as staff for his Hotel at the beginning of the universe. They manage to defeat him and free man's ancestors from a life of low-paying minimum wage jobs.
The Tick and Arthur are chosen to teach Superhero School and a classroom of unlikely heroes. They must rush into action to take on Uncle Creamy, a corporate mascot turned into a evil ice cream cone who strikes out at the company who made him. Meanwhile Uncle Creamy II attacks, trying to kill Uncle Creamy before he tells the heroes what the company is up to.
