Brain uses an enlarging ray to make himself and Pinky four hundred feet tall. With Pinky dressed as a Gollyzilla, Brain stages a fight to make himself look like hero. But then the real Gollyzilla shows up. / Brain makes Pinky smarter so his stupidity won't ruin anymore plans. / Pinky and Brain perform a song about the brain.
Brain gains the ability to cloud the minds of men with his voice. He tries to get on the radio by adapting the persona of "The Fog". Unfortunately his plan falls apart when he gets to the studio. / Brain hears that a space probe is about to be launched. On the probe is a plaque with a representation of man and woman. Brain changes the plaque to make it appear that he rules the world. Aliens discover the probe and take Pinky and the Brain to their planet where they honor them just like they are "honored" on Earth. / Pinky sings about cheese.
The Brain hatches a plan to take over the world by using static electricity to shock the world into submission. Unfortunately he needs several billion dollars to build a giant clothes dryer. Pinky and the Brain head to Island X where they set up a fake country and hope to get a giant foreign aid loan from the United States.
Brain develops a special pair of dentures that can produce a smile that can hypnotize anyone who is not wearing a special pair of sunglasses. In order to take over the world, he needs people to see the mesmerizing smile. He figures that he needs to get on TV and in order to do that he has to become a celebrity.
While France awaits Napoleon's triumphant return from Austria, Brain develops a recipe for exploding crepe-suzettes in an effort to conquer France. He uses the recipe in a cooking class and when the crepes explode, he is arrested. When he is taken to prison, however, his luck begins to change when people mistake him for Napoleon Bonaparte.
Pinky and the Brain head to the North Pole. Pinky just wants to see Santa, but the Brain has a more sinister plan. He wants pretend to be an elf so that he can mass produce a hypnotic doll named "Noddle Noggin" in Santa's workshop. He then hopes that Santa will distribute the toy all over world so he can take over.
Pinky searches for the Brain in post-World War II Vienna. He misunderstands people when they try to tell him the Brain is dead and his misunderstandings lead to a series of misadventures. / The Brain captures two mice for an experiment to aid in a plan for world domination. He discovers however that the two mice are his parents.
Pinky writes a letter to the newspaper criticizing the comic strip "The Family Circus". His letter, however, is misunderstood as a political statement that thrusts him to a spotlight that leads him to the Presidency of the United States. Pinky's administration, however, must deal with a scandal when the Brain's plans to take over the world are made public.
Brain enlists the aid of beavers to gain control over the flow of rivers. / The mice make a series of comedy films and hit the big time.
Pinky and Brain have a new companion, Larry, but their newest plan just doesn't seem to pan out. / In their latest plan, Pinky and Brain try to take over the steel mills in Pittsburgh, Pennsylvania by pretending to be a part of an endangered species called the Mousealopes.
Brain gets caught up in winning a golf tournament, even though it interferes with his new plan. / After the Earth gets the power of speech from his Silitronlinguifactor device, Brain comes up with a new plan.
Pinky becomes a guru during the 1960s. / It's Brain's birthday and Pinky plans a surprise party.
Brain sings about past and present world leaders' failures. / The mice need to get into a mine, but have to pretend to join a Amish-type society.
Brain becomes a tap dancer with steam-powered legs in order to spread a subliminal morse code at the World's Fair. / Brain is out of ideas for taking over the world, so he tries to get some from writers.
Brain creates a cloning machine and plans to clone himself in order to create the best Celtic dance troupe the world has ever seen. / Brain masquerades as a fashion designer.
Brain plans to use the Personalitron to give him irresistible charisma, but it winds up going to Pinky. / The mice learn of a secret organization, T.H.E.Y. (comprised of world leaders), and try to get in.
Brain's attempt to control Emperor Franz Josef get side tracked when he talks about his problems with psychiatrist Dr. Sigmund Freud. / Brain enters the world of a sumo wrestling to acquire a paralyzing fish.
Brain takes control over aquatic mammals for his latest plan and Pinky falls for a female sea lion. / Brain tries to change the Earth's weather patterns.
A well-meaning tailor makes Pinky and Brain's lives miserable. / At a sleep away camp for world leaders' children, Brain tries to trick the children into placing listening devices in their parents' offices.
To release Brain's leather repellant, the mice become baseball players. / Brain's latest plan for world domination is the Schpiel-Borg 2000, which hosts a retrospective of past episodes.
Spoofing Winnie the Pooh, Brainie and Pinklet try to steal honey from a bee hive. / Brain tries to create chaos in Hamlet's family and take over.
Pinky has his own plan for world domination and Brain goes along with it. / Brain explains why he should be leader in a mock educational film.
Pinky and Brain masquerade as a mother and child star respectively to get money needed for the next plan. / Pinky sings a song about saying "narf".
It's another usual night where Brain plans to take over the world, only it's seen from Pinky's point of view. / The mice sing about world domination. / Brain opens a restaurant and feeds the customers a drug to make them smarter.
Pinky and Brain's plan to alter caviar with a mutating capsule is complicated by a Russian lab mouse. / Brain plots to make every clock on Earth chime repeatedly.
Inspired by legends of the past, Brain tries to create a legend about himself to gain world acclaim. / How Acme Labs became home to Pinky and Brain.