The lonely and frustrated Seiji Sawamura ["Mad Dog Sawamura"] wakes up one morning and finds his right hand has turned into a girl named Midori. Midori, who has been deeply in love with him for three years, and who has been watching him from afar, is not as upset with the current situation. Now Seiji must find a way to deal with his new life with Midori. But right now, Sawamura is more interested in two female admirers who would like to come over and meet him...but after being rejected 20 times in a row, Sawamura cannot believe his good luck...
After an accident, Seiji and Midori relize she needs some new clothes. So after some thought, they go to a doll shop. After Takamizawa Shuichi, a fellow student discovers that Seiji collects dolls, Seiji pretends to be his friend and have the same hobby to keep his mouth shut. But how long before Takamizawa discovers thier secret?
The school physical education instructor has a grudge against Seiji and plains to take it out on him in gym class. Seiji has another problem after he mistakenly takes some of Orin's [his sister's] booze thinking it was medicine, to fight his cold, but soon passes out. How will Midori handle an afternoon with no Seiji? And who keeps ringing the doorbell?
Seiji's neighbor Shiori decides she doesn't want to go out with her father and stepmother for the day, because she hates her stepmother. So Seiji ends up watching her instead. Ayase, still trying to get the courage to ask Seiji out, sees them walking together and soon believes Seiji is a pervert. How true are her fears? Is Seiji really a pervert?
Kouta, Midori's old school friend soon discovers Seiji and Midori's secret. He pleads with them to let her mother know what has happened to her...but with no luck. Elsewhere, a shaman explains to Midori's mother that Midori's 'spirit' does not want to return to her full-size body yet, and all they can do is wait. Will Midori return to full-size soon? Will Kouta tell Midori's mother his secret?
One morning, Seiji discovers that Midori is gone and his right hand is back to normal. Later, Ayase finally tells Seiji she is in love with him, but he can not return the remark because...he has fallen in love with Midori!! Midori is now awakened from her coma, but remembers nothing about the past weeks. Will Midori and Seiji end up together? Can their relationship go back to what it was when she was his right-hand?