Pop loses Cub, but then finds him playing in the mud. Then, however, while he bathes Cub in the kitchen sink, when he makes the mistake of leaving to pick up the phone, he causes all sorts of trouble for him.
Cub and Pop buy a puppy that seems harmless at first, but attacks them. Lumpy attempts to catch it, but the puppy escapes and goes insane whenever it hears a whistle.
Nutty takes a bag of sugar from the café while on his way home, but then drops the bag of sugar on a pile of cement bags and unknowingly takes a bag of cement home. When he eats the cement afterwards, he ends up in an ambulance, but the bridge it is on is made of sugar.
Petunia catches fire on her tail while making pancakes. The fire then spreads to Giggles, and then the whole house. Mime calls the firefighters for help, but things do not go well.
Giggles confronts Lumpy when she catches him emptying his garbage truck in a lake. She has The Mole, Sniffles, Pop, and Cub clean up his litter, but Lumpy will not stop his dreadful pollution.
At Petunia's lights store, she throws away a lamp that supposedly doesn't work. When Lifty and Shifty take it from the trash, however, they find that it is a magic lamp with Lumpy the Genie inside. As it is passed between Happy Tree Friends, their wishes result in death.
Nutty trades his cow to Lifty and Shifty for some magic jelly beans. The next day, he and Giggles' house is in the sky after a beanstalk grew out of Nutty. Giggles meets a giant (played by Lumpy), and must stop him, for he is making food with a nasty recipe.
When Splendid attacks Lifty and Shifty, they use Kryptonut as a distraction to make him puke violently and fall sick. Whenever he tries to stop them, he fails because they have the Kryptonut in possession.
Disco Bear eats deep fried butter, causing him to suffer a heart attack. Lumpy removes the butter from Disco Bear's heart, but his heartbeat stops. As Giggles pumps life into Disco Bear's body, Lumpy has to find a replacement heart.
When Pop thinks that Cub fell into a well, he enlists the help of Sniffles, Lumpy, and The Mole to rescue him, which leads them through a mayhem-filled adventure.
Handy fails to build a house for Giggles, so he gets help from his friends. Unbeknownst to them, Lumpy is using the blueprint paper to fold a crane as they create a house for her.
Disco Bear has a burnt hair strand, but his barber, The Mole, cuts off everything but his sideburns. Now he has to get his hair (and his beloved afro) back or he'll face humiliation.
Lumpy and Sniffles find an injured Giggles outside her house. Apparently, she has a bad cold, and Sniffles wants to cure her – but chaos ensues when Lumpy catches the cold and accidentally injects Sniffles into his own body.
Cuddles auditions to join the Happy Tree Band to replace former member Russell, who has been electrocuted. Despite some difficulties, Cuddles gets the part, but then the real chaos begins during the band's performance.
Flippy consults Lumpy the psychiatrist upon becoming aware of his Post-traumatic stress disorder which generally results in flip outs, killing everyone, and innocent people as victims. But when they keep on happening, Flippy eventually ends up in a heated battle with his evil side.