Ren and Stimpy need new jobs, so they disguise themselves as Dalmatians, go to work for a psychotic fire chief, and battle a 40-story building fire, saving Mr. Horse and others! During the story of "The Littlest Giant," Ren drifts off and dreams that he is Wee Ren, a resident of Thumbsville who makes the mistake of befriending the littlest Giant, Stimpy.