Out in the Wild West, an ignorant sheriff and his dimwitted deputy hire villains to steal Mr. Horse so that they can have a hanging. Who are the lucky villains? You guessed it. Ren and Stimpy hit the road as door-to-door Rubber Nipple Salesmen, peddling their wares to a bizarre clientele, including a psychotic Fire Chief, a paranoid Mr. Horse, and a family actually in need of new nipples!