Young Jun comes home from school to find a package waiting for him. He opens it, and although he is no enthusiast, he finds the most well crafted antique style doll he has ever seen. It's when he winds up its key, however, that everything begins. Destructive sister dolls start their own little drama, flying in and out of his poor, repeatedly broken window, a weepy sister doll comes crying for help, a crazy disembodied, a crazy sister doll comes body snatching... it's all a little much for Jun, but he is an affirmative action kind of guy, and he's not the type to ignore "people" who need his help, so he dives in.
ひきこもりの少年・桜田ジュンの元に「まきますか まきませんか」とだけ書かれたダイレクトメールが届いた。《まくこと》を選択したジュンの元へ届けられたのは第５のローゼンメイデン真紅。
そしてジュンの前に次々と現われる個性豊かなドールたち。なし崩しに真紅のしもべとなったジュンは、ローゼンメイデンの命とも言える《ローザミスティカ》を奪い合うアリスゲームに巻き込まれる。
