Parker schlägt sich mit dem Motto "gar kein Problem" und seinen besten Freunden Mikey und Jerry durchs Teenagerleben. Mit Schwester Shelly und Direktorin Musso als "Gegenspieler" haben sie es dabei nicht leicht.
The series depicts the tribulations of the title character Parker Lewis, a Santo Domingo High School student, for whom nothing is impossible. Parker often narrates in shows. Just like his best friends, Jerry Steiner and Mikey Randall and his girlfriend Annie Sloan, his prime concern is achieving and maintaining "coolness" during the turbulent years of puberty. However, their efforts are often thwarted by Parker's little sister, Shelly, and principal Grace Musso. Apart from various aspects of teenage life, embedded in a surreal, living-cartoon-like quality and the clever camera angles and filming techniques (dissolves from one scene to the next were done by ever larger pixels), an episode regularly contains more or less subtle references to movies, politics, and celebrities. The 3,100 students are called "Flamingos", after their football team.
Parker Lewis est un lycéen qui passe son temps à faire les quatre cents coups avec ses deux meilleurs amis Mikey et Jerry. Cependant la directrice Mlle Musso et sa sœur Shelly Lewis perturbent tous leurs plans.
A série retrata as atribulações de Parker Lewis, aluno do colégio Santo Domingo, para quem nada é impossível. Assim como seus melhores amigos Jerry Steiner e Mikey Randall e sua namorada Annie Sloan, sua principal preocupação é passar pelos turbulentos anos da puberdade com estilo. No entanto, frustrar os seus esforços é a meta de sua irmã, Shelly, e da diretora Grace.
Relatada en primera persona por su personaje principal, Parker Lewis, relata las aventuras de un grupo de tres amigos: Parker, Mikey y Jerry (este último más que un amigo era una especie de asistente), en el Instituto de Enseñanza Media Santo Domingo durante los bulliciosos años de la pubertad.