In the milestone 100th episode, “Lois’ Sister,” Lois’ younger sister, Susan (Laurie Metcalf), pays the family a visit and brings with her expensive gifts for the boys, biting remarks for Lois and a cold shoulder for Hal – whom she has never forgiven for dumping her for Lois. Lois and Susan’s competitive relationship takes a turn for the worse when Susan gives Malcolm and Reese her prize ’65 Mustang convertible. But when Lois discovers that Susan needs a kidney transplant, she puts her anger aside and offers to donate her kidney to Susan, which Susan only sees as the perfect opportunity for Lois to one-up her.
Name | Type | Role | |
---|---|---|---|
Gary Murphy | Writer | ||
Jasmine Di Angelo | Guest Star | ||
Josh Jacobson | Guest Star | ||
Laurie Metcalf | Guest Star | ||
Chanel Gaines | Guest Star | ||
Tianna Danielle Kenney | Guest Star | ||
Lyndsy Fonseca | Guest Star | ||
Kate Lang Johnson | Guest Star | ||
Abigail Mavity | Guest Star | ||
Heather McPhaul | Guest Star | ||
Montana Tsai | Guest Star | ||
Alyssa Monka | Guest Star | ||
Gracie Markland | Guest Star | ||
Hayley Erin | Guest Star | ||
Kevin Cooney | Guest Star | ||
David D'Ovidio | Director |