Ami gives Yumi a career test and it comes out as Ninja, so Yumi becomes a ninja using her at home ninja kit, complete with bio-degraitable ninja monkey for a teacher, but she takes the ninja thing too far...
Ami is driven to the brink of insanity, while trying to find a bunny huggles doll out of her favorite cereal "Super Rainbow Blast" so she can make a "Super Cuddle Love Hug."
Manager Kaz begins a new gig involving baby "reincarnations" of Ami and Yumi known as the "Mini-Puffs".
When Ami and Yumi inadvertently best a bull while attending a bullfight in Latin America, they’re regarded as heroes. Now the town expects them to fight El Diablo, the toughest bull in the country.
Ami signs herself and Yumi up to a dance contest. But when a competitor stubs Ami's toe, it's up to Yumi to use her rock star knowledge to win.
Ami and Yumi have to pay the rent for the bus when Kaz came up with the idea and they get a job as taffy makers at Wacky Wally's candy factory.
A new group playing Metal called Metal Breath comes to the Puffy bus on tour with them and Ami & Yumi must get them out before they stay only the opening band for concerts!
Kaz orders robot-type clones of Ami & Yumi, but when he orders a whole fleet of them, it's up to Ami & Yumi to stop the robot fleet before they lose their rock-star jobs!
Ami and Yumi accidently let 3 bandits out of jail and then they are blamed for it and are on wanted posters, so they decide "showdown" with the bandits!
The duo stops a villain, so the superhero group "Team Teen" grants them superpowers and they join their team, but they soon find out Team Teen follows teenage restrictions and is the lamest group of superheros... ever! But when they are in trouble, Ami and Yumi must go to their rescue!
Ami receives a visit with her romantic-poetry-writing pen-pal Pierre. Unfortunately, her "dreamboat" turns out to be both a certified geek and a certified bore, whose idea of a romantic date involves entomology, volunteer work at the library, and chess.
Ami and Yumi go to visit their friends on the Happy Acres Farm, only to find things aren't so happy: the farm is in shambles, and a greedy developer is threatening to buy the land from its kindly owner and build a parking lot. To keep this from happening, Ami and Yumi offer to help fix up the farm, but that soon proves easier said than done.
When Ami convinces Yumi to join her in a surfing competition, Yumi reluctantly agrees. It isn't until the girls are hit by a giant wave and stranded at sea that Yumi realizes Ami doesn't know how to surf.
A rich man pays Kaz for Ami & Yumi for his bratty little son, Timmy. Ami & Yumi learn that he's more trouble then he's worth, how will they escape from him?
Ami and Yumi get abducted by aliens.
Kaz thinks Yumi might be allergic to Ami and needs a break away from her.
Yumi is forced to wear some funky headgear that forces her to smile, in order to prevent scowlitis from taking hold of her.
Ami & Yumi eat cheap sushi, and end up in a whacked-out undersea voyage of a hallucination.
Kaz is force to care for Ami and Yumi's cat while they have the day off.
Kaz loses Ami and Yumi on a bet of Rock-Paper-Scissors. The new manager who won gives them an amazing lap-of-luxary. But after missing Kaz, they give him a chance to win themselves back...
A famous director shoots a music video, but when Ami & Yumi have to perform dangerous stunts, they find the video is more trouble than it's worth.
Kaz opens a Puffy themed restaurant that the girls have to work in. The girls must get a good review on the restaurant for the sake of the Puffy name.
During a concert, Ami and Yumi both break their instruments at the same time. Kaz tells them that that gives them 100 years of bad luck, and then they keep getting jinxed. Will they be able to stop getting jinxed before their bad luck lasts longer than anyone's ever lived?
Kaz keeps disturbing the cats' beauty sleep. So the cats play devious tricks on him when he goes to sleep himself.
Mean Machine: Puffy finds a man with a robot that plays music, but then the robot plays the music and becomes popular. Ami and Yumi must regain their title.
Exhausted from eight straight months of touring, the girls are delighted when Kaz surprises them with tickets to a ocean cruise. Little do they know that the cruise is a seniors cruise and that Kaz has booked them as the ship's band. Will Ami and Yumi be able to get the old ship singer his job back, or are they stuck for a tenure?
Kaz almost runs over a squirrel who left his home due to Eldwin Blair chopping down trees for toothpicks, Ami and Yumi decide to help the squirrel get his home back. Later on, Ami chains her and Yumi to the tree. Eldwin starts up the bulldozers and chases them through the forest until he surrounds them. Ami manages to convice Eldwin to save the tree.
Ami and Yumi come back to their tour bus and find a note that Kaz left saying that he had to go to the hospital. Ami and Yumi go to one to visit him but the nurse kept saying that visiting hours aren't right now and they have to wait until the end of next month. Ami and Yumi keep trying to get in the hospital with the nurse chasing them. They get in a room with a guy who looks like Kaz but was taller. Eventually, The nurse catches them and throws them out. Ami and Yumi are sad but when they come back to the tour bus they find Kaz there and they find out that Kaz just went to the pet hospital for their cats.
Unlike Ami and Kaz, Yumi has never won a trophy before. Intent on winning one, she enters a tofu-dog eating contest. When she entered her first contest she lost. She challenged the champion to a rematch and if she won she got the champion's golden teeth, But if she loses, she and Ami must spit polish and clean his teeth for the rest of their lives. When the champion and Yumi get ready, Yumi starts out slow and the champion is winning but Kaz says mentions the baseball game they went to and Ami starts playing baseball. Yumi starts eating the Tofu-dogs fast and ends up winning the champion's gold teeth.
Yumi is tired of Ami always waking her up early, so Yumi sets Ami's clock backwards by 5 seconds. The clock affects Ami as she loses her sense of timing.
Yumi is tired of Ami using her stuff without her permission, so Yumi gets a security system that attacks whoever comes into her room. But, the security system soon targets Yumi. Can she find a way to stop it?
Kaz has a party in a hotel room and doesn't invite Ami and Yumi, now the girls try to sneak into the party.
Ami takes Yumi outside in the wild for some fresh air after she had been in a room for almost a week. Then, Ami gets kidnapped by Bigfoot. Can Yumi save her friend?
Ami and Yumi end up in prison after Kaz mistakes them for crooks.
When Kaz is too short to go on a ride, Ami and Yumi must disguise him(And themselves too) so he can go on the ride. Can they get him on the ride? The name of the episode is a reference to "The right stuff".
Kaz is sick of being bald so he gets some hair growing liquid to grow his hair back. But suddenly, something scary happens! He becomes a Werewolf! He chases the cats around the bus.
Ami and Yumi are transported to the year 3000 where they discover the whole world is dedicated to them.
Kaz books a ski trip for him, Ami and Yumi. Yumi wasn't a good skier so Ami signed up Yumi for ski school so she could get better But Yumi gets mad and lies to Ami and says that she passed. Ami finds out she didn't and Yumi said there were monkeys and little kids in the class. They start fighting and then start rolling down the hill. Meanwhile, Kaz is trying to skate across a frozen lake. While rolling down the hill, Ami and Yumi crash into the cabin and break all the bones in their body. In the end, Kaz uses Ami and Yumi as skis to ride down the mountain. The name is a reference to Seasick.
Fed up with the cats scratching up his stuff, Kaz tries to build Jang Keng and Tekerai a scratching post. The name puns Law &Order.
Chad, The good card game player of Stu-Pi-Doh comes back and has a new girlfriend named Janice. Ami and Yumi start to like Chad again and they start getting Jealous of Janice and they start to follow them everywhere to see what they do together. While following them and getting information of what Janice likes Ami and Yumi change to try to be more like Janice so Chad will like them again. They start dressing and acting like her. Chad falls for them and Janice gets sad and runs off. After hanging out with Ami and Yumi Chad starts to not like them. Later on, Janice comes back and tells Chad that she joined a rock band and she had hair like Ami's. Chad said that it ruled she was in a band. Ami and Yumi get mad and just keeping saying that they rule until the end of the episode.
Kaz, had it with Jang Keng and Tekirai, tries to frame them for various crimes. The name puns Cat Food.
When Kaz goes out and buys and a dog that looks just like him things start going crazy! When big time company owners come Kaz isn't there but Domo is! So can the girls get back before the company owners leave?
Yumi gets fed up with Ami and Kaz giving her all the hard work, so she wishes that there was no such thing as Puffy AmiYumi. Her wish came true, but Ami and Kaz are now having a hard life, and Yumi realizes how miserable she is without them.
Ami and Yumi are visited by an old friend named Atchan who thinks he's a superhero. Can Atchan help Yumi when she, Ami and Kaz are kidnapped by the giant snake monster Sunikura?
Ami's bad attempt at and album cover is discovered by an art critic who suggests to Ami that she should become an artist.
After breaking Yumi's new guitar, Ami tries to convince Yumi and Kaz that she saw a unicorn. This is the only episode where no dialogue is heard in this episode.
Ami and Yumi compete with each other to complete a world record.
Kaz enters the cats into a racing contest, much to Ami and Yumi's disapproval.
Ami thinks Yumi and Kaz are dangerous drivers, so she makes them take driving classes.
Ami and Yumi tried to save lobsters from a seafood restaurant.
Kaz is tired of how Ami and Yumi are playing, so he seeks the help of phantom rocker, Johnny Ghost. Ami and Yumi then get trapped in his haunted mansion.
Ami adopts a hunk of fungus that comes from their shower.
Ami and Yumi become slaves in a country.
Ami, Yumi and Kaz compete against Axel and Rod Skidmark in a soap box derby.
The Talent Suckers seek a job in order to pay off some debts.
In their childhood years, Ami and Yumi arrive at Camp Youwannasushi and are met by Atchan, who tells them about Rumaki the bunk monster. Yumi is grabbed by Rumaki and Ami and Atchan go under the bed to save her. They manage to save Yumi, but she does not believe them because she was in the sack for the whole episode.
The girls and Kaz try out for a sitcom, hoping for good reviews but recieve continuous bad reviews.
Ami and Yumi win 1 million Yen. They have to think of a way to spend it all in only 6 minutes.
The girls need to find a way to hide their rock-star lives from Ami's grandmother incase she suffers a heart attack.
The Talent Suckers use zombies to increase their popularity, but it proves ineffective.
A gang of bikers attacks a city. The girls must stop them before they take it over.
Ami, Yumi and Kaz are too old to be rocking and need to find other enjoyable things to do.
Ami, Yumi and Kaz have trouble with a mime named Si. And need a way to get rid of him.
The girls play a game of Truth or Dare.
With the help of the girls, Kaz trains to become a sumo wrestler and has his first match.
The girls go to a prom in the jungle, but are in danger of missing it.
When Yumi accidentally injures the tooth fairy, she and Ami become tooth fairies for one night. But soon they meet a little boy who would do anything to keep his tooth.
Ami joins Kaz's football team, not knowing that this is a dangerous sport. Kaz tells the security guard not to let Yumi in, because he does not want her to stop Amy playing. Yumi dresses like a cheerleader and gets in. Seeing that Ami doesn't have a chance against the other players, Yumi helps her without Ami realising it.
The show is spoiled because the animators fall asleep. Yumi has Kaz's voice, Ami has Yumi's voice and Kaz has animal voices.
Kaz tries to find a way to carry Ami and Yumi's instruments to their next gig without the need of a tour bus.
Ami, Yumi, and Kaz get lost in space as they head to their next gig.
When Ami and Yumi shrink in the drier to mouse size, they need to find a way to get back to normal size while being chased by their own cats.
When Yumi is struck by lightning, she is sent to an alternate universe where everyone is evil. Meanwhile, Yumi's evil counterpart is put in Yumi's place and wreaks havoc.
Kaz accidentally knocks out a horse named Butterscotch, and Ami and Yumi dress up as the horse to help Kaz out at a rodeo.
An alligator named Waldo appears and startles Ami and Yumi. The girls then try to get rid of him.
Ami's cell phone overuse causes Kaz to take her cell phone away, leaving Ami to find alternate methods to communicate with other people.
Ami and Yumi travel back in time to become disco stars.
The girls are denied access to the Rock Legends museum since they've never trashed a hotel room. Ami and Yumi try their best, but the plan becomes thwarted by an efficient maid.
Kaz gets sent into a manga where he is captured by Mr. Maestro. Ami and Yumi try to rescue their manager with the aid of two heroes, a pencil, and an eraser.
Julie (Lara Jill Miller) comes for a visit. She does nice things to Yumi, but mean things to Ami(Such as calling her Arthur and pretending she doesn't exist). When they go to their concert, Julie is not treated as a star. When the concert is over, she goes to a dark alley and plots revenge.
Evil scientist Ami and her assistant Yumi create the perfect manager, "KAZ". When Harmony, their Number 1 villager, gets into their castle, the monster escapes and gets into Harmony's house. When he leaves again, he pushes over a table with candles on it, causing the house to burn down. Harmony gets angry and organizes a mob of villagers to storm the castle. Meanwhile Ami and Yumi are making another monster. They hear the door-bell and, when they open the door, Harmony and two other villagers run into the castle and start to destroy it. Suddenly Kaz comes back and Yumi finds out that he had only been behaving strangely because he could not see. She gives him glasses and then he convinces the villagers that they are not mad scientists, but musicians. To thank Kaz, they make a wife for him. This is the series finale.