With the school on hiatus the students pursue personal interests - but the break is anything but quiet. Trouble lurks as Charlie and Gina search for the missing diamonds, Farida tries to shake off her past and Healy and Nancy appear to be on a self-destructive journey.
Half the class visits a "tent city" on the outskirts of Sudbury where they endeavour to help a host of people living in a makeshift shanty town. From a pregnant intravenous drug-user to a man stuck with porcupine quills, the students do what they can to help. Charlie finds financial relief (or so he thinks), and Melanie comes face-to-face with the man she wrongfully accused. Dr. Helvi tries to prevent Dr. Healy from descending further into a personal hell.
Charlie's unauthorized prescription to a prisoner puts both he and Farida in jeopardy, Melanie is intrigued by an inmate's cannabis cure for White Hand Syndrome; Eva and Gary have a confrontation with a racist police officer and Dr. Cardinal rekindles an old friendship, all while trying to talk Dr. Healy through a recurring nightmare.
Gary and Cameron find themselves ,trapped, at a fly-in only camp with television fishing show icon, Sam Pisano. Charlie tries to make good on a promise to a prison inmate, while Melanie tries to patch things up with a miner she wrongly accused, and Gina learns something about Dr. Dallaire's personal history with Dr. Healy.
During a Tornado disaster simulation in an isolated campground, Dr. Helvi's patience is tested by both the students, the role playing actor's and a ,real, casualty that turns up with unusual symptoms. Charlie and Farida help out a victim of a roadside accident, and while attending to her ex-husband who is in a coma, Nancy gets a surprise visitor.
Melanie and Gina try to help a wheelchair-bound octogenarian through a suicidal crisis. Charlie tries to make good on a promise to an inmate but gets inadvertently drawn into a financial mess. Nancy learns some unsettling news from Warren's fiancée while Gary tries to help out a junkie, inspiration strikes Cameron and Dr. Healy's isolation takes its toll.
Gary and Charlie attend an autopsy conducted by Dr. Helvi and learn some unsettling news. With Warren out of his coma, he and Nancy have a heart-to-heart and Dr. Healy nurses a shotgun victim back to health. Farida tries to help Erica find a good home for her two boys, and Gina and Eva find Charlie's missing goat.
A seemingly healthy Dr. Healy tries to get his job back and Farida tries to atone for her sins. Cameron tries to build bridges with his father and Charlie gets caught in a lie to Tara; Gary has a crisis of faith and Eva's cousin, Trevor, gets much more than he bargained for when his girlfriend Amanda gives birth.
Sent out in pairs, the students shadow an emergency medical team, do shifts in a hospital ER, attend to a street kid with frostbite, and keep a watchful eye on Mylo, a teenage cancer patient who has a steroid induced vision during a First Nations Full Moon Ceremony.
Gary gets a taste of northern justice with a side helping of racism, Cameron and Gina find out drug addiction isn't just for the young, Eva and Mel try to talk Mylo into resuming chemo, and Charlie's marital counseling session implodes.
Charlie and Gary rescue a lumberjack with severed fingers. Gina and Cameron come face to face with an elderly, over-prescribing doctor, and Farida deals with the death of a patient and close friend. Nancy suspects two monks of having AIDS.
Cameron and Gina look in on a patient and find a surprising illegal enterprise. Charlie moves in with his dad. Farida struggles with grief. Cameron's art forgery threatens his career. Nancy gets schooled by Helvi for jumping to conclusions.
Farida's poor performance review surprises the faculty. Nancy treats a retired hockey enforcer with signs of PTSD. Charlie steps in between Gary and a racist cop. Eva mishandles confidential information. Cam discovers Gina's rescue project.
Eva eases Amanda's return to the Rez to meet the baby she ran out on. Melanie helps Mylo find her way back to treatment for her leukemia, and Healy confronts Farida about her drug use, while Gina's animal rescue operation is busted.
Cancer free Kyle comes to town, making Eva question her choices. Charlie takes the kids but double books himself, getting into hot water with Tara. Cameron and Gina receive complaints, forcing a new understanding of medical ethics.
An altercation with racist cop Sid puts Gary's med career in jeopardy. Nancy thinks up a unique idea to help her concussion patient get over his depression. A rift between Eva and Bonnie erupts at Melanie's bone marrow drive on the Rez.
Dallaire confronts Gary about his assault on racist officer Sid. Eva and Bonnie's relationship blows up publicly. Gina's apology to a patient goes awry. Charlie gets news that may put an end to his dream of a medical career.
In the season premiere, Farida treats a child with a superficial injury, and gets a front-row seat to a custody battle. Charlie comes clean to Dallaire about the encounter between Gary and a dirty cop. Following a bone-marrow donation, Eva asks for a transfer out. Dawn arrests on Cameron's watch, Gina is wheeled into the ER after her assault, and Nancy deals with the aftermath of a patient's suicide.
Charlie wants to keep things as normal as possible while Tara begins chemo treatment. A judge orders Gary into reconciliation classes with a racist cop. Farida crosses the line with Erica's ex-husband, Nick. Recovering from a bone-marrow donation, Eva ends up doing more caregiving than self-care, and Cameron checks in with Gina, who is suffering retrograde amnesia after her assault.
Mel and Gina begin their placement with the disorganized, addicted and cranky Dr. Kesler. Mylo boomerangs back into Eva's care as Bonnie begins treatment for her Hep-C. Farida skips therapy and chooses to unburden herself to a long-suffering Dr. Healy. Mould in Charlie's house has him showing up with his family on his father's doorstep moment's after Eddy shows a home invader the business end of his shotgun.
Farida tries to care for a little girl while trying to fend off her warring parents. Dr. Kesler reveals his Achilles heel to Gina. Charlie and Gary respond to a distress call to a hoarder's apartment. Nancy receives a special delivery from Sergio from beyond the grave. Mel suspects a case of elderly abuse and Cameron makes a questionable diagnosis.
Gina and Cameron get a shock after treating a gunshot victim. Nancy receives a surprise visit and request from her eldest son Sean. Marley's biological grandmother shows up on Eva's doorstep, sending Amanda and Trevor into a tailspin. Mylo learns the truth behind her father's death.
Nancy finds herself at odds with Dr. Helvi over her handling of a teenage girl's case. Farida discovers the reason behind Krista's mysterious rash. Dr. Kesler brings Gina on a house call with disastrous consequences. Eddy finds yet another way to get into trouble with the cops - and Charlie. Cameron's multiple missteps land him in disciplinary trouble with Dean Dallaire and Melanie rescues an Elderly patient abandoned in the hospital ER.
Gina and Melanie find Dr. Kesler going through withdrawal forcing Gina to step in and make a tough call. Gary's unorthodox approach to a reconciliation session ends up backfiring. Charlie's discovery of Eddy and Tara's collusion ends up very badly for an avian dream home. Helvi and Nancy's relationship reaches a breaking point. Farida lays down the law with Krista's parents and Melanie helps her elderly abuse patient regain some of her personal autonomy.
The good news about Tara's progress is dampened by Charlie's bad news about the house. Eva tries to deal with Marley's grandmother while trying to protect Amanda and Trevor. Nancy's attempt to send Sergio off into space brings her face-to-face with a life and death situation. Gina sees Dr. Kesler through rehab with some tough love. On an EMS ride-along with the dirty cop, Gary and Charlie save a life and learn the cop's secret. Farida deals with heartbreak.
In the series finale, Cameron's comes clean about his ethical breaches and his career as a doctor hangs in the balance. Eva turns a song into a dream for Mylo's future. Gina and Mel receive an offer they can't refuse. Nancy finally figures out the transition from Nurse to Doctor. Farida has to do the hardest thing any doctor has to do and Charlie thinks he's lost everything but learns that sometimes, good guys don't finish last.