One Chicago focuses on the professional and private lives of the firefighters, police officers, emergency medical personnel, and legal professionals who serve the city of Chicago.
The lives of firefighters and paramedics working for the City of Chicago Fire Department at Fire Station 51, made up of Truck 81, Squadron 3, Ambulance 61, and Battalion 25.
Detective Sergeant Hank Voight and his elite Intelligence Unit at the Chicago Police Department combat atrocious offences and bring criminals to justice.
An emotional ride through the day-to-day chaos of the city's most explosive hospital and the courageous team of doctors that holds it together. They will tackle unique new cases inspired by topical events, forging fiery relationships in the pulse-pounding pandemonium of the emergency room, and through it all, familiar faces from the Chicago Police and Fire departments will intertwine as this third team of Chicago heroes hits the ground running.
Just like their brethren in the Chicago P.D., the State's Attorney's dedicated team of prosecutors and investigators navigates heated city politics and controversy head-on, while fearlessly pursuing justice. As they take on the city's high-stakes and often media-frenzied cases, they must balance public opinion, power struggles within the system, and their unwavering passion for the law. And it all starts with a gut-wrenching case when one of Chicago's finest is shot in the line of duty.