1916年,褚韶华为救哥哥褚韶中而嫁给陈记药铺的大少爷陈大顺,她以诚信和出色的商业才能得到陈父的赏识,成为药铺管理人。陈父和陈大顺意外去世后,陈二顺继承药铺并败光家财,药铺陷入绝境。褚韶华在艰辛努力下,开了华顺药铺养活一家老小。褚韶华决意携手初恋情人夏初开启新的生活,却遭陈二顺和陈母的阻挠。陈家被土匪洗劫一空,褚韶华也在这次劫难中失去女儿,伤心不已的她独自出走上海。褚韶华在上海永新百货业绩突出,受经营奇才闻知秋之邀共同创业,逐步成长为胆略过人、重诺守信的女商人。
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