A flood is threatening a Chinese temple, home of an ancient Hand Fan, which the God of Wind has sealed away. The Trekkers are sent to retrieve the Fan before the temple floods, but Mip's secret fear of water gets in the way of the Mission. Mip learns that sharing fears with others makes them better. His Trekker friends' empathy and understanding help Mip face his fear and they all have a successful Mission.
The Trekkers go to Ireland, where Mo has tons of family, to find a mythical Golden Harm whose music is said to bring harmony to even the bitterest of rivals.
An exciting visit to the Mouse Museum of Natural History turns into a mission when the Trekkers discover that the mousterious disappearance of bones and artifacts has led to the closing of the museum.
The Trekkers are sent to a spooky castle to find a missing Ruby Brooch that could indicate the return of Nosferatu
The Trekkers travel to Africa to find a stolen Tribal Mask - Central to a rain dance for a local tribe who is suffering a drought.
When the Tooth Fairy Disappears, the Trekkers go hunt for her in Tooth Fairy land. Kids all over the world won't get their treats! But they discover she is just sad because as an artist, a beautiful sculpture - her masterpiece! - has gone missing.
A rare sighting of Nessy, the Loch Ness Monster, has put her in danger from a Monster Hunter's hi-tech boat. The Trekkers race to Scotland and have an underwater adventure in a special Trekker Submarine to try and find Nessy and protect her. Mip's fears of Monsters however taints his view of Nessy, until they discover she has a baby, and is actually just a kind animal, frightened of being captured. Mip bonds with the Baby Monster, and revises his view of what makes something a Monster. He ends up taking a heroic stand to protect Nessy and her baby from Monster Hunters once and for all.
Mip accidentally convinces Mo that he is unlucky, so when the Trekkers Journey to a Wild West ghost town to find a Lucky Charm gone missing, Mo is determined to find a Lucky Charm of his own.
When the Trekkers, Ms. B, and Professor Katmandu all start nodding off to sleep continuously, the Trekkers must travel to a great Sand Desert to try and fin Mousephus, whose Sand Clock has apparently run amok!
The Trekkers are sworn to secrecy about their mission to clean plastic from the ocean and protect a rare, endangered Flower Fish whose location must be kept secret.
Professor Katmandu selects Mip to take care of his prized plant while he is away on a trip. Mip doesn't take this duty seriously and the other two Trekkers, as always, step in when Mip shirks his responsibilities.
Professor Katmandu's dotty old British explorer friend, Dr. Rodenthal, has disappeared in the depths of the jungle, as he investigates the existence of an ancient Incan Device called the Sun Eater.
When the fabulous Lens of Hope goes missing from a Mouse Lighthouse, ships bearing a year's supply of cheese for mice everywhere are put in danger. Without the Light to guide them, they will crash on the rocks.
The Trekkers journey to Japan to protect an ancient Cheese Grater, central to a Japanese ritual conducted by the Emperor each Equinox to bring good luck to all his people.
Mip is upset when he realizes he's forgotten Mac's birthday and hides the fact that he has no present for her by making up stories. Mo tries to reassure him that its the thought that counts but Mip cannot be consoled.
The Trekkers discover that long ago, Professor Katmandu failed in a mission and thinking he has kept it a secret, vow to find it for him.
Mac gets an alert on her Library Hotline that a Bookworm has invaded the Museum Library, which holds the precious Book of Lost Treasures. They rush to try and find the Bookworm.
Mac, Mip, and Mo are summoned to the mission room where Professor Katmandu gives them what they think is an insignificant mission to transport a heart-shaped amulet, The Heart of Wisdom, to be cleaned for the Museum.
The Professor and Ms. B dispatch the Trekkers into the densest jungle of Rodentia to find a lost temple rumored to house the fable treasure, The Golden Idol of the Monkey King. Mip is thrilled - this quest is right up his alley.
The mission is to find lost treasures of the fabled Ratssunkamin in a pyramid in Egypt before a sandstorm buries the artifacts.
When the Trekkers are summoned to the mission room to learn they are to assist a real princess, Ondatra, daughter of Neptune, King of the Sea, Mo is star-struck.
Without a mission, the Trekkers are bored playing cards and games to while away the time. Professor Katmandu has a plan to create an adventure right in their own back yard.
The Museum is visited by a former celebrity Trekker, a friend of Professor Kat, whose portrait hangs in the hall of distinguished former members.
Mo is obsessed with a new multiplayer video game just as the Trekkers receive a mission call for help on the remote island of Krackatalon.
Mo is driving his bike around the Museum with training wheels when Mac offers to take them off. Mo is embarrassed to admit that he is afraid to ride without them.
The Trekker’s read about an ancient feud between two Pirate Clans and a lost bottle with a message inside. What could the message be? A treasure map? Off they go to the Caribbean only to find two arguing, retired pirates who don’t even know why they feud. What they discover is the bottle and a lost message that clears up the feud. The truth heals and shines a light on friendship.
The vroom-vroom of toy racing cars in the Mouseum leads the Trekkers on an adventure in their own home, through a secret basement entrance to a treasure trove of Trekker memorabilia and a map left by Maurice, the founding Trekker. The adventure and the episode is about deciphering the clues left by Maurice for future Trekkers leaving behind clues that ties teams together to find their own treasure.
In a mission gone wrong, the bickering trio faces Ms. B and Katmandu to explain what happened, but no one tells the same story. Katmandu has each to explain their version mission from their own perspective. After they finished their stories, Ms. B reveals that a drone followed them recording the adventure and as they review the actual events, they learn something about truth and one’s own viewpoint.
In an out of this world episode the Trekkers are sent into outer-space to retrieve a recording device housed in a space probe that crashed on the dark side of the moon. The difficulties and challenges of the mission issues show the Trekkers how each respond to the demands of their experience and how they treat other people’s feelings. Comedy and jokes go a long way in making it a successful mission demonstrated by the processor of artificial intelligence of the probe, Wayfarer.
Mo’s favourite holiday, Rodentide, a celebration of musical sharing and inclusion is threatened when the precious bell that heralds in the holiday, The Tintinnabulum of Rodentide, is discovered missing. To save the bell and the holiday the Trekkers must empathise and understand the point of view of the Marmoyeti, the cute monster, who made off with the bell to his cave. The Trekkers show the townspeople how to include him in their festivities and capture the spirit of the holiday.
Mac and Mip debate each other’s approach to everything, seriousness vs having fun. A mission comes in from an island off of Greece, a call for help from a theatre director, where the ancient masks of Comedy and Tragedy have also gotten into an argument and the emotional balance of all life is frozen when the two masks split up. This is a fast- paced sitcom with a background of ancient Greek theatre as the masks split apart and then come back together in harmony.
An urgent call for help sends the trio on an adventure to find the missing never-ending cuckoo clock. Junior, a small boy living in a very large and lonely mansion filled with toys places the call for help and only the Trekkers discover quickly both the missing cuckoo clock and Junior’s loneliness. The mission is a success when they recognize that the valued treasure of this mission is friendship.