Ruth Ojadi is the first person that Reggie meets, and initially he finds it very difficult to deal with her constant physical and verbal tics. But seeing how people on the street react to Ruth, it is quickly brought home to Reggie that living with Tourette's is no easy task. Ruth started ticcing aged 16, and by her early twenties the Tourette's became unmanageable. She was forced to quit university, where she was studying music, and give up singing altogether. 25-year-old Steve plays the piano and guitar, as well as singing. His Tourette's is severe and, as well as the verbal outbursts, Steve's body is constantly jerking. Reggie discovers that when Steve performs his tics completely disappear, only to start again the moment he finishes a song. Sick of being defined by their condition, for one night they will step from behind the shroud of Tourette's and out into the limelight. But as the six meet for the first time, Reggie realises just what a mammoth task he has taken on.
Reggie Yates continues on an extraordinary journey to put on a live musical event with six young people who all have Tourette Syndrome. Reggie has barely started before he is forced to realise the monumental task he has taken on when 15-year-old Jake arrives at rehearsals with his hand bandaged - his Tourettes that often makes him punch himself, has made him punch a wall instead. Meanwhile, Ruth starts ticcing even when she sings, and Emilly's nerves are so bad she cannot sing a complete song. With a public catastrophe looming, Reggie turns to Ed Sheeran, Eliza Doolittle, and Aloe Blacc for help. But will it be enough to turn things around?