Igor steals Dr. Vic's love potion and uses it as a perfume for Natalie Nightshade, a once-famous Hollywood actress who now haunts the castle, but the potion has a dangerous side effect that may cost Igor his life; a monster movie parody about reptilian creatures; Igor traps Phil inside a giant popcorn machine as part of his lesson on the big bang theory; Melissa Screetch incurs the wrath of the Tooth Fairy after refusing to give half of her Tooth Fairy money to her brother Kyle.
Igor creates a humanoid baby with an insatiable appetite; another B-movie parody in which a monster known as "Everything" plots to rule the world; Igor teaches viewers about lightning, but cannot stop getting struck by it; a musical take on Little Red Riding Hood starring Melissa Screetch torturing the Big Bad Wolf.
While on his way to a mad scientist's potluck, Dr. Vic learns that his rival (now reduced to a head after eating Vic's nine-alarm chili) booby-trapped his car to explode if it gets below 60 miles per hour; a short commercial parody for a breakfast cereal made of fish; Ashley sets up a kissing booth at the school carnival; Igor pushes Phil off the Eiffel Tower in this warped lesson on gravity; Melissa Screetch gets her teacher fired for making her stand in the corner as punishment for talking during class.
Dr. Vic switches Santa Claus' brain with the brain of a bank robber; Fred is sentenced to overnight detention and must escape by traveling through the school's air vent to save his date for the school dance from the school bully; Igor sings about the periodic table; Melissa swallows watermelon seeds, which grow inside her and turn her into a freak.
While Dr. Vic is away, Igor and Phil use the castle as a bed and breakfast—and the Grim Reaper becomes their first customer; Fred takes his dead dog to a dog show; Igor sings about the evolution of man; Melissa Screetch spins her own tale about Christopher Columbus and his exploration of America, which includes a hungry sea monster.
Igor, Dr. Vic, and Phil appear on a Dating Game-style game show, where Dr. Vic keeps getting injured during the physical challenges; the Deadmans head to the mall for a family photo; Igor literally picks Phil's brain during a song about the organ; Melissa comes down with a serious case of Pinocchio nose when she will not stop lying and incurs the wrath of God.
Phil ingests all the chemicals in the lab to wash out the taste of the five-alarm chili Igor made, and suddenly becomes the smartest person in the world, which Igor and Dr. Vic want to exploit for their own benefits; the Deadmans vacation in Hawaii, where they are mistaken for an ancient god; Igor sings about the universe; Melissa's candy bingeing causes her to waste away from not eating real food.
Dr. Vic's grandmother comes to visit, and Igor thinks Phil accidentally spiking her tea with wolfsbane has turned her into a werewolf; another B-movie parody, this time, about a lobster monster ruining a teen beach party; Igor teaches viewers about the scientific reasonings behind luck; Melissa Screetch is an obnoxious mermaid bent on revenge against the prince who rejected her.
Igor resurrects Dr. Vic's ex-wife and her family; Fred and Ashley sign up for the school talent show; Igor sings an Elvis-inspired song about earthquakes; Melissa Screetch harasses the Three Bears.
Igor tries to get Phil's brain to help him out with taking out the trash—but Phil's brain is lonely and wants a bride; Fred goes on a mini-golf date with a Goth girl; Igor sings about the effects of bites and stings to the tune of "My Favorite Things" from The Sound of Music; Melissa Screetch's excessive couch bouncing sends her into space.
Dr. Vic forces a tired Igor into remodeling his bedroom and Igor replaces Phil's brain with the brain of an interior decorator; the Deadmans meet their new human neighbors at a barbecue; Igor sings about how having a parasite for a pet is cheaper than a real animal; a field trip to NASA leads to an alien invasion, thanks to Melissa Screetch's meddling.
After discovering that they are broke, Dr. Vic and Igor take jobs at Weenie on a Twig while Phil is mistaken for a video game at the local arcade; Fred and Ashley Deadman play with their French cousin who wants to get rid of Ashley and live her life; Melissa Screetch is a lazy, nasty Cinderella in this boogie-woogie take on the classic tale.
Igor gets a new job with a different mad scientist after Dr. Vic refuses to give into his demands; a Brady Bunch parody starring the Deadmans.
In this parody of My Fair Lady, Igor trains Phil to be the stand-out of the Westminister Monster show after Dr. Vic refuses to let him enter; the angry villagers recite a poem about a stranger with a strange nose; Phil sings about the many brains he has in the lab and in his head.
A movie crew invades the castle and Igor, Dr. Vic, and Phil fight back; a B-movie parody where a sleepy Western town is attacked by an overgrown woman with 50 feet; Becki (the Weenie on a Twig supervisor from "Something Weenie This Way Comes") performs a piece on why she hates being on Toonsylvania.
Dr. Vic, Igor, and Phil endure a boring visit to the DMV after Dr. Vic gets a misprinted license plate; a B-movie parody in which aliens want America to switch over to the metric system; Melissa Screetch creates her own TV show where her babysitter is sent to an Alcatraz-style prison island.
Dr. Vic sells his fountain of youth potion on an infomercial; the Deadman kids are expelled for being dead; Melissa wishes for a Black Ops helicopter; Dr. Vic's maid Madame Olga sings about her secrets and dreams.
Igor, Dr. Vic, and Phil go time-traveling; Dr. Vic hosts his own cooking segment; a network censor with P.O.T.T.I (Parents Opposed To Television Inappropriateness) speaks out against the show's violent content; an Igor/Phil segment gets toned down by the censor from the previous segment; a newsreel parody shows how the Deadman family changed history; an unknown extra points out the scenes he appears in on the show; a B-movie parody about a swamp monster who wants to go on vacation.
Phil falls in love with a female monster, but Dr. Vic ends up stealing her; a parody of Shakespeare's Richard III has Igor as the protagonist; the Deadman kids fight back against their bullies; Melissa Screetch's wilderness group gets lost in the woods.