Melvin Junko falls in a vat of chemicals and instantly becomes hideously deformed creature with super human size and strength. Dr. Killemoff the evil alien from another world wants to take over Tromaville. Toxie is the only one stopping Killemoff from his evil plans for world domination, but he can't do it alone. Both Major Disaster and Nozone aid Toxie in defending Tromaville from Killemoff and his goons: Psycho, Bonehead, and the radiation rangers!
Czar Zosta attempts to invade Tromaville by hot air balloon filled with toxic fumes. To keep the Toxic Crusaders busy, Dr. Killemoff organizes a convention for hideously deformed creatures of superhuman size and strength. Meanwhile, Mrs. Junko ends up working as Dr. Killemoff's "Girl Friday" when Mayor Grody raises the rent of her house.
THE TOXIC CRUSADERS, led by Toxie, a creature of superhuman size & strength, are America’s favorite environmental heroes! The TOXIC CRUSADERS wage an ongoing war of laughs against crime, corruption and chemical waste. In order to save Tromaville and the rest of the planet, the TOXIC CRUSADERS must thwart the plans of the evil Dr. Killemoff, a mutant pollutant from the planet Smogula, and his hoards of heinous henchmen.