Jimmy Fallon premieres as the new host of The Tonight Show, welcoming his first guest Will Smith and a performance from U2.
| Name | Type | Role | |
|---|---|---|---|
| A.D. Miles | Writer | ||
| U2 | Musical Guest | ||
| Kim Kardashian | Guest Star | ||
| Will Smith | Guest Star | ||
| Lady Gaga | Guest Star | ||
| Rudy Giuliani | Guest Star | ||
| Seth Rogen | Guest Star | ||
| Stephen Colbert | Guest Star | ||
| Mariah Carey | Guest Star | ||
| Lindsay Lohan | Guest Star | ||
| Robert De Niro | Guest Star | ||
| Tracy Morgan | Guest Star | ||
| Sarah Jessica Parker | Guest Star | ||
| Tina Fey | Guest Star | ||
| Joan Rivers | Guest Star | ||
| Mike Tyson | Guest Star | ||
| Joe Namath | Guest Star | ||
| Spike Lee | Director |