Museum Man uses his Skeleton Simulation gun to bring the dinosaur skeletons to life in a plot to take over Big City.
A cruise ship that the Globetrotters are on crashes off the coast of Bongo Zuny where a big game hunter named Bwana Bob plans to hunt the Globetrotters and the people on the cruise.
A nuclear-powered alien named Facelift plots to steal the faces of the World Leaders and place them on his Demon Droids in order to gain control of the world.
Whaleman uses the mechanical whale Moby Whale in order to steal supertankers containing 50 tons of oil as part of a plot to control the world's oil supplies.
To help in his revenge on G.G. Godfrey, Robo builds robotic duplicates of the Globetrotters to commit a crime spree that ends up framing the real Globetrotters.
A space pirate named Tattoo Man is on a gold-robbing spree.
Movie Man plans to steal a top secret mystery robot. Crime Globe warns them that the mystery robot in question is filled with Globetron.
While visiting Miss Jenny on her Bar-B-Q-Ranch, the Globetrotters learn that the Phantom Cowboy is responsible for various attacks in Tombstone Valley. The Crime Globe states that the Phantom Cowboy is actually a remote-controlled zombie and now the Globetrotters must find the person controlling it.
Time Lord invades the Time Research Center in order to steal a time machine called T.I.M. (short for Time Isolation Machine). He uses his criminals from history to help him.
Count Bragula and his Transylvania Terrors plot to take over Transylvania and place it under their control. The Globetrotters are called in to keep Count Bragula from taking over Transylvania.
Bull Moose steals the Goose that Laid the Golden Eggs in order to complete his golden ray and take over Breadbasket City.
Merlo the Magician and his Knights of the Crooked Table are stealing the world's monuments.
Attila the Hun and his Huns follow Professor Herbert George through his Time Transporter. When they cause havoc in San Francisco, the Super Globetrotters are called in to stop Attila the Hun and return him to his own time.