Plastic Man takes on the Weed, a walking sentient plant who robs a university of its plant growth formula in order to create his own plant monster in order to take over the world's capitals, starting with Lima, Peru. The Weed fails to realize his mutated plant monster may not behave like other plants.
The puny Dr. Irwin Feldspar finds a meteor that transforms him into the powerful Mr. Meteor giving him a Jekyll and Hyde personality. Mr. Meteor is too much even for Plastic Man, but Penny might become a big help.
A sentient clam with a pirate captain-motif, called "The Clam" steals a water-controlling machine from the Chinese government. The Chief tells Plastic Man the machine is in Italy, however, that was a false report by the Clam's hoods, leaving New York City undefended for the Clam to make a tsunami, evacuating NYC and flooding it completely except for the top floors of the tallest buildings, allowing the Clam and his underlings to commit robberies as all the banks and department stores are now submerged.
Dr. Honctoff is stealing all of the oceans and seas around the world by using a secret formula to turn them into vapour and then bottling them. Plastic Man is called into stop Honctoff's dastardly deeds.
While working on a secret government project, Professor Darwin's experiment goes very wrong. The mistake is costly as it leaves Professor Darwin (quite literally) half ape and half human. As Half-Ape, he plans to steal a visiting flying saucer to start an interplanetary war.
Hugefoot steals a device that can make people see into the future and even makes off with Penny.
A group of small gangsters called the Miniscule 7 plot to win basketball tournaments their way. It's up to Plastic Man to stop them.
Moonraider is stealing NASA's spaceships in outer space.
Dr. Superstein plots to steal the minds of people to power his monster army.
Dogmaster plans to steal the formula for a power ray that has been hidden in a chimpanzee's brain.
Doctor Dome discovers a way to extract Plastic Man's superpowers and uses them to commit crimes.
Honey Bee plans to use a heat missile to turn the world into a 'hot house' so that only she and her insects will survive.
Doctor Dinosaur uses his dinosaurs to help rob banks and national landmarks.
One by one, the Spider starts to turn Queen Katherine's follower's into flies until she decides to marry him.
An airplane carrying the children of an important official crashes in the forbidden zone of Stone Island, which is run by a sinister group known as the Empire of Evil. Plastic Man and his friends are sent to rescue the children and return them to safety.
When Carrot-Man steals a map that will lead him to a cosmic scepter, Plastic Man must stop Carrot Man from getting to it.
Computerhead is an evil robot that has developed a device that can bring any machine to life. He then sets out to create an army of machines to take over the world.
Hippotist is hypnotizing bank managers to rob their own banks and return the stolen loot to him.
Plastic Man must make a plan to stop an evil genie that is abducting teenagers at an alarming rate. The genie grants wishes to teenagers that want to win. He then turns them into a statue of gold and takes them for his collection, and his next target is Penny's nephew who is in a track & field competition. Plastic-Man had once fought Badladdin before, and the villain is determined not to lose a rematch.
Toyman is kidnapping famous people everywhere and is turning them into toys. Unfortunately for Plastic Man, he is the last person on Toyman's list to abduct.
Plastic Man learns that Ghost Finger has returned to get revenge on the people responsible for sending him to prison. He uses a time machine to bring other evil ghost from the past in to help him get his revenge.
Highbrow steals the world's most famous trains so that people will have to pay him to travel on them.
Kitty Katt discovers an Egyptian serum that can turn anyone into cats.
Commodore Peril holds the prized possessions belonging to three billionaires for ransom.
Solex uses his solar weapon to spring Weed, Half-Ape, Clam, Computerhead, and Disco Mummy from prison in order to lead them. However, they don't agree with his terms. When Solex starts disrupting their crimes, the five villains turn to Plastic Man for help.
Joggernaught plans to steal an energy machine in order to use it to find the treasure of the Amazon City of Gold.
Doctor Duplicator is kidnapping politicians and replacing them with evil duplicate clones in order to steal government secrets.
Thunderman has stolen New York City and plans to sell it to the highest bidder.
Count Graffiti wants revenge on the Royal Family of Ocentania after being exiled from the country. He plans on stealing the royal crown in order to make himself the new king, but Plastic Man has other ideas and plans on stopping his scheme.
Desperate for a sale, Gearshift Swift sells Earth to passing aliens. Now Plastic Man must save Earth from being pulled from its orbit by the aliens.
An ancient Aztec Queen called Disco Mummy comes back to life and steals the ancient treasure of Cortez from the government of Mexico. She tricks Plastic Man into helping her and then turns him into a mummy. He must find a way out if he is to have a chance to stop her.
The elderly Dr. Frost finds the city of ice and in it the power of eternal youth. After learning its secret, she plans on reversing the gases effect and use it on the world. Plastic Man has to stop her evil scheme to turn the world's population into old people.
Dr. Astro has created a giant plastic ape and is using it to ransack New York. Plastic Man is called in to thwart his evil schemes
Greta Grim has designed the ultimate hi-tech villain suit. In order to sell it she films a commercial starring none other than Plastic Man.
The evil Gargoyle is hell bent on stealing Doctor Ventor's invisible ray machine. Luckily Plastic Man stumbles across the plan and decides to prevent the Gargoyles scheme.
