The World Health Organization claims heart disease is the leading cause of death in the world. Could evolution be key in understanding this disease? Over 220 million years, mammals gradually acquired outstanding athletic ability through incremental improvements in the heart. However, 7 million years ago, several stages in early human evolution caused the development of heart disease risk factors. For example, by standing upright, the burden on the heart was increased, and in exchange for our larger brain, the seeds of heart attacks were planted. This program examines how the human predisposition for heart disease was the price for evolution.