Ostracized for having a bald scalp, Petey Pate turns to villainy and kidnaps Pearl to make Mouseville take him seriously.
Lonely orphan Scrappy hears Pearl out about Mighty Mouse's beginnings.
Mighty's new pal Durf tries to fit in with mouse society but is rejected, forcing them to go to Cat Town where Durf finds a new friend.
Scrappy helps a sick tooth fairy, but is pursued by a wicked witch. Mighty Mouse comes to the rescue and calms the witch.
While Mighty Mouse is on vacation, Bat-Bat and sidekick the Bug Wonder step in to save Vermin City from some dairy food changes caused by the Cow.
Scrappy tries to fit in with a shady gang, but he and the gang are sold to the carnival. When the going gets tough Mighty Mouse is summoned to the rescue.
After a long and exhausting aversion of disasters, Mighty Mouse discovers that a hiccoughing cat is the source of all this.
Mighty Mouse takes Scrappy on a field trip to prehistoric times, braving much danger throughout.
Scrappy is captured by Mr. Maxie, who intends to commercialise mouse burgers. Mighty Mouse finds out about this puts a stop to it.
The Cow finds a cosmic cheese to beat Mighty Mouse. Despite multiple contacts with it, Mighty is able to avoid letting it overwhelm him.
An alien cat is claiming Mouseville, but he does not prove to be a threat and his conquest is short lived.
In this episode, footage from vintage Terrytoons cartoons play in time to "The Loco-Motion" and "Why Do Fools Fall in Love."
Polly Pineblossom is refusing Mighty's help, so he solves minor problems until he finds out that Big Murray is upsetting Polly.
The mutated giant kitten Puffy is terrorizing Mouseville. After a brief fight with Mighty, some aliens take Puffy to a place where he will be welcomed.
The Cow defeats the League of Super-Rodents to impress Madame Marsupial, but is beaten by the Rampaging Sloth.
The shady gang sneak into the Mouseville Cinema and combine old Terrytoons Mighty Mouse clips.
The Glove imprisons Mike and Pearl, and they and Scrappy head off to his brother Lefty for help. Mighty takes care not compromise his secret identity.
Thinking no one remembers his birthday, Scrappy moves away with a hobo named Slappy. After Mighty Mouse rescues them, they are surprised with a birthday celebration.
A. Crab mistakes Pearl Pureheart for his fiancee and kidnaps her. Mighty's friend Aqua-Guppy brings A. Crab's real fiancee to him.
Old Terrytoons cartoons play in sequence to a jazz concerto song about Mighty Mouse.
Gandy Goose thaws from an iceberg, but he's lost without Sour Puss. Mighty is overwhelmed by Gandy's antics, but he manages to reunite him with Sour Puss.
The shady gang are abducted on a pirate ship and after a mutiny are deceived by the pirates. They wake up from this staged nightmare ready to reform.
Mighty takes Scrappy to meet Elwie and the Tree Weasels. At tonight's concert Mighty saves the Mouseville Orphans' benefit from going to ruin.
Mighty must defeat villains from the Crimebusters Comics that have come to life, while an alien force invades Mouseville.
After Big Murray's ransom scheme backfires, Mighty Mouse and the Mighty Heroes are out to capture rampaging stolen numbers.
An overworked Mighty Mouse tries to recuperate but old Terrytoons Adventures makes him restless. However he gains his needed strength.
Petey Pate forms a rebellion to overwhelm cats. Shocked by the mice's bullying Pearl protests and Mighty comes to her rescue and restores order.
The Cow bails out Oil Can Harry, who wastes no time pursuing Pearl, but his visit to Pearl becomes stressful and he wishes to go back to prison.
Sour Puss and Gandy try to bring Pearl and Mighty together for marriage. After a long hesitation, Mighty reconsiders about the marriage.
Mighty Mouse is charged with Scrappy's disappearance. As the case nears to an end, a monster Scrappy approaches. All this time Scrappy was having a nightmare.
Bat-Bat is sent to stop Ski Nose's numerous thefts of golden awards all with Mighty Mouse's assistance. Ski Nose is a caricature of Bob Hope.
Mighty Mouse and Pearl go inside the president's body to cure his cardiac ailment within one hour.
Mighty Mouse reads out to a television program designer his sequel of Snow White heading to Detroit.
A little boy switches Mighty Mouse from channel to channel, until Mighty Mouse breaks out and convinces him to do something different.
Petey Pate builds Supermice robots to replace Mighty Mouse, but they become corrupted, so Mighty terminates them.
Twenty years later, Mighty is married to Pearl, running a motel and raising their son, but is threatened by Howard Hack (a parody of Howard Roark from Ayn Rand's The Fountainhead) rivaling with his own motel.
Mighty heads to Hollywood to become a star, but The Cow seeks to sabotage his position, but instead Mighty co-stars with him.
Mighty Mouse has the villains watch some previous episodes of Mighty Mouse, with many interruptions throughout.
Terrytoon original theatrical shorts as bonus material on the DVD set: "He Dood It Again," "Gypsy Life," and "The Mysterious Package" represent Mighty Mouse shorts from different time periods.
