George H.W. Bush volunteers to go to war; he is reunited with Barbara and they give birth to their first child, future President George W. Bush; tragedy strikes when they lose their daughter Robin; Prescott Bush heads for the Senate.
Blinded by loyalty to his president and ignoring the advice of his family, George H.W. Bush is betrayed by Richard Nixon; the children start to follow in their father's footsteps; young Jeb gets married to Columba; George W. falls in love with Laura.
George H.W. Bush becomes a loyal vice president to Ronald Reagan, but his wife Barbara falls out with First Lady Nancy; George W. commits to a life of sobriety while becoming the father of twin daughters.
The Bushes have finally made it to the White House, but having a father as a president hits Neil Bush hard when scandals strike; George H.W. triumphs against Saddam; the Bush family suffers a bitter election defeat and the loss of their matriarch.
George W. and Jeb Bush are two brothers determined to make it to the Governor's mansion but only one will succeed. Laura Bush fears the consequences of having a second president in the family but she can't stop her husband becoming "43."
President George W. Bush strives to secure the second term his father never won. But the war he started in Iraq will define his presidency and cast a long shadow on the Bush family.