After Iron Man stops an A.I.M. arms trade, Hank Pym talks with Mad Thinker to see what he meant when he referred to the villains in the super prisons as soon being free. All four of the prisons then break down and each hero deals with this. Meanwhile, Leonard Samson is exposed to Gamma radiation when the Cube deactivates and is injured by Zzzax. Hulk escapes with Samson and heads to the nearest civilized area. Graviton escapes the Raft and seeks revenge on Nick Fury.
A flashback to 10 years before reveals Graviton's origin. In the present, Iron Man is outnumbered by old enemies at the Vault. To escape and fight Graviton, Tony self-destructs the Vault, but his armor was damaged and he radios a replacement from his Chicago tower. Thor, Hank Pym, and Wasp try to fight Graviton. Later, they are joined by Hulk and Iron Man and with their combined power they defeat Graviton and form the Avengers in order to catch the 74 escaped supervillians that escaped the four prisons.
While searching for the fire demon Surtur, Thor is attacked by a powerful creature known as Beta Ray Bill, and the unthinkable happens when Bill lifts Thor's hammer as the two battle. Thor must ally himself with this strange warrior to save Asgard before Surtur and his demon army burn it to the ground.
The Enchantress, as part of her master Surtur's plan, offers Loki a chance to exact his revenge on Thor and the Avengers for thwarting his conquest of the Nine Realms, and uses a spell to strip Thor, Captain America, and Iron Man of their powers. Now, the helpless heroes must defeat Loki - his soul now in command of a powerful Asgardian weapon known as the Destroyer - without their abilities. NOTE: This episode was skipped in US airings, but included on the Avengers: Earth's Mightiest Heroes boxed volume Secret Invasion as a bonus episode. Marvel released a clip of the episode, adding that it is "an un-aired episode available exclusively" on the DVD. This episode is part of the regular airing schedule on ABC Australia, and eventually broadcast on Disney XD in the US on May 5, 2013.
A mysterious explosion seemingly kills Hank in his college laboratory, but as the Avengers and their friends mourn the loss of their fallen comrade-in-arms, a fearless new vigilante - endowed with the same powers and technology as Ant-Man/Giant-Man and Wasp and calling himself "Yellowjacket" - begins taking out the members of the Serpent Society.
The Vision awakens after a month of repairs to find that Tony Stark and his fellow Avengers have taken over the world. With the whole planet turned against him, the Vision must get to the bottom of Tony Stark's 'utopia' - only to discover an unlikely figure to be the true power behind the Avengers' throne. Based on the 1987 Marvel graphic novel Emperor Doom (albeit with a different cast).
Strange fumes sicken all of the Avengers - save for Iron Man, whose suit of armor provides him with protection. Now the armored Avenger must race against time to synthesize a cure for the infected - while the team face the prospect of being quarantined by U.S. Defense Secretary Dell Rusk, who has sent Doc Samson, Falcon, the Red Hulk and the Winter Soldier to arrest them. When Captain America is captured by the Winter Soldier and brought before Dell Rusk, he learns that the enigmatic Secretary harbors a diabolical secret from the supersoldier's past. Based on Avengers: Red Zone.
When the Hulk's name is cleared of the crimes committed by the Red Hulk, the Avengers find that the deception put forth by Captain America's Skrull doppelganger has made the green-skinned juggernaut even more of a loose cannon than before. Meanwhile, the enigmatic Red Hulk returns with a scheme to usurp the Hulk's place among the Avengers.
Kang the Conqueror is freed from prison by his alternate timeline look-alikes and attempts to conquer the world once again, this time trapping the Avengers in a temporal void to keep them from getting in the way of his plans. Now a new team of heroes (Spider-Man, War Machine, Wolverine, Iron Fist, Luke Cage and the Thing) must band together to stop the cross-temporal onslaught.
From the very moment of their team's inception, the Avengers have fought against super-villains, time-travelling conquerors and even shape-shifting alien invaders. But now they must bring forth an army of nearly all their allies to face their greatest challenge yet - Galactus, the devourer of countless worlds and civilizations, and his quartet of heralds drawn from the very elements of nature.
King T'Chaka is challenged to a duel by Man-Ape for control of Wakanda.
It's Hawkeye, Black Panther, and Ant Man to the rescue when Baron Zemo and his Masters of Evil defeat the rest of the team and take over the Avengers Mansion.