The Chest of Demons is stolen by a Shadow Demon, so the gang is off to Befuddle Manor to get it back. But reception problems with Mr. Van Ghoul's crystal ball leave him unable to warn them that Befuddle Manor is a maze which is nearly impossible to escape. To make matters worse, there's an evil monstress in Befuddle Manor who presumes the gang still has the Chest of Demons and she'll stop at nothing to acquire it.
Boguel and Weird send the gang an phony telegram signing vincent's name and plant a mirror that's a door to a another world when the gang enters their room their will be pulled into that world unfortunely the plan backfires and pulls the maid into the ghostly world and the gang is accused of her disapearance.
After a confrontation with Time Slime which results in Scooby reliving memories of ghosts from the past, Scoob decides that he's done with the ghost-chasing business. The gang decides to replace him, so they hold auditions and Flim-Flam decides on casting the lovable, lazy puppy Bernie Gumshire. But hapless Bernie is no help when Time Slime captures the gang. It's up to Vincent Van Ghoul to pay Scooby a visit and show him what the future will be like if Time Slime defeats his friends in this send-up of It's a Wonderful Life.
Evil demon Demondo has plans to release monsters from comic strips all over the world with the help of his magic ink pen. But before he begins his global domination, he wants to destroy Scooby and the gang. So Demondo sends Bogel and Weerd to deliver a special edition newspaper and the gang becomes imprisoned in the funny papers. The magic pen (which is literally the key to escaping) gets lost under a rock in the Missing Link strip, so the gang enlists the aide of Platypus Duck, the Wacky Wizard, and thier other new funny paper friends to help them track the pen down.
Ghosts that they defeated in their past come back to haunt the Scooby gang and they must figure out a way to vanquish them once and for all.
Shaggy discovers that his uncle Col. Beauregard has died and left him his country estate, which is apparently frequented by ghosts. Shaggy, Scooby and Scrappy head for the estate in order to claim Shaggy's inheritance.