Hazuki Oikawa is introduced. She comes to Kaoru and Takuma's dorm room and kills the bacteria they were planning to cultivate. Everyone is summoned back to the lab where Professor Itsuki and Haruka show them how to make sake for educational purposes.
菌を培養してひと儲けを狙う川浜と美里だったが、除菌が趣味の及川葉月により菌は死滅してしまう。一方、樹教授は新しい発酵蔵の起工を祝ってお酒造りを実演、沢木は菌の活動で酒ができる仕組みを目の当たりにする。