Stephen has highly aggressive jaw cancer and undergoes ground-breaking surgery to save his life. Hilary is suffering from a rare carcinoid tumour and faces a complex procedure with a 40% risk of death.
Following a liver transplant, an operation to remove a rare cancer of the soft palette, and a particularly nasty open fracture of a woman's lower leg.
If surgeons don't operate on Pratyush soon, his tumour could push him into a coma, before killing him. Mariella needs a ground-breaking procedure for a recurring bowel cancer.
Laura, 29, has an incurable brain tumour. To extend her life, she needs it removed. But the hugely risky surgery will have a drastic effect on her memory and may even kill her.
A risky operation on a 66-year-old's massive aortic aneurism, a complicated procedure to remove an angiosarcoma, and an operation which carries a significant risk of facial paralysis.
Gary has a rare tumour lodged in his spine. Leaving it in place will probably lead to paralysis, but an operation carries a huge risk. Margaret has developed a spontaneous hole in her skull.
Sajid has a massive aneurysm above his heart. If it bursts, he will bleed to death. Margaret needs an urgent operation to remove a tumour from the lining of her brain.
Surgeons face a challenge as Susan's aggressive cancer spreads from her upper jaw to her eye and nose - and removing it will leave a significant hole in her face, which will need complex reconstruction.
Syed's life hangs in the balance as his testicular cancer spreads into his heart. Consultant urological surgeons must undertake a radical plan to remove the tumour, with help from cardiac surgeons.
ENT surgeon Shahz Ahmed prepares to operate on Sarah, whose large bone tumour is pushing into her skull. And Mike, who has pancreatic cancer, is having a high-risk but potentially life-saving operation.
Claire has a tumour growing at the bridge between her brain and her nose. And if her surgeon can't mend the hole he has to make in her skull to get the tumour out, she risks developing meningitis.
A cardiac surgeon performs a heart transplant on mother-of-three Katie after a three-month wait in hospital. And 75-year-old grandfather Edward needs life-saving surgery for aggressive kidney cancer.
