Josh and Chuck's boss, Steve, brings a man who suffers from alien hand syndrome to the office for the guys to do a podcast about him. The man's hand has a grudge against Josh, and Josh suspects all is not what it seems. In their podcast, Josh and Chuck discuss brain anomalies including alien hands, split brains and dual personalities.
In episode two, in preparation for their podcast on forensics, Steve sets up a ride-along for Josh and Chuck with the Atlanta police department. As Josh and Chuck shed their staunchly-held beliefs based on TV series, the yin-and-yang duo of Detectives Johnson and Hillburn open their eyes to the realities of life on the force. The guys focus on forensics and the "science in the service of justice" for their podcast.
Construction in the office stirs up a bee colony living inside a wall, and we find out the hard way that Chuck is allergic to bees. Steve is inspired to adopt the bee colony managerial style, with herself as queen. For their podcast Josh and Chuck discuss bee colonies, hive intelligence, social order, colony collapse and allergies.
When the star pitcher of their office softball team is injured, Josh and Chuck do some homespun experiments in cloud seeding in hopes of causing a rain-out. Josh and Chuck use their podcast to talk about weather modification, from air conditioning to cloud seeding and hurricane steering during peacetime and war.
In this episode, news reports of flesh-eating bacteria at Chuck’s gym threaten to derail his new workout routine, but Steve sees the situation as an opportunity to investigate a local story. As an illness befalls the office, Steve suspects bacteria from Chuck’s gym, and sequesters Josh, Chuck and Jeri until they have been inspected by a most unusual doctor. During their podcast the guys discuss necrotizing fasciitis, antibiotics and the concept of super-bacteria as well as bionic bacteria that eat oil spills or track E. coli in food.
When corporate office promotes a company-wide time capsule initiative, the office is excited. While some people contribute thoughtful tokens to represent these times, Josh and Chuck concoct a plan to contact future time travelers. With some help from world-renowned physicist
Josh and Chuck notice that a rival podcast has recently covered four of the topics they have discussed, leading them to wonder if this is more than a coincidence. Fellow office podcasters, The Conspiracy Guys, get involved, and Josh and Chuck begin to suspect Jeri of betraying them. This leads to the guys talking about spy recruitment, gadgets, double agents and misinformation campaigns for their podcast.
One of Josh and Chuck’s colleagues, Kent, begins suffering from extreme sleepwalking. Josh and Chuck do a series of studies in an effort to help understand and cure him of his sleepwalking. During their research the guys discover Kent has been violating Steve’s office in his sleep. For their podcast Josh and Chuck discuss the complex things people can do while sleepwalking, only to wake up not remembering anything, sleep hacks to ensure you get optimal sleep, and what happens when you don’t get enough sleep.
In this episode, Steve holds a trivia competition to decide which podcasters win a VIP tour of a design facility for space travel. Josh learns that elusive SpaceX owner Elon Musk will be present and the tour turns into a competitive event between Chuck and John Hodgman. The guys discuss in their podcast the struggles of NASA and the decision to move forward on the privatization of space travel. The main focus is the future of space travel, colonization and what it could mean for humanity.
In this episode, the series goes back to the beginning when the new boss, Steve, is introduced and brings a high-tech coffee machine with her to the office. It doesn’t take long for the staff to discover that the coffee machine appears to have a mind of its own. Josh and Chuck use the opportunity to talk about technological singularity (greater than human intelligence through technological means), the emotional lives of robots, and the future of humanity during their podcast.
With a shared love of random knowledge, average-joes Josh and Chuck find success as podcasters. As they explore Body Dysmorphic Disorder and real Zombies, boss-lady Steve’s voracious appetite for promotion ignites serious self image issues and threatens to hurt their street cred.