Sketches include Hillary Election Video Cold Open, Taraji P. Henson's I Made It Monologue, Depend Legends, Teacher Trial, Home 2, QVC, Game of Thrones, Weekend Update: Cecilia Gimenez on Lucille Ball Statue, Weekend Update: Jacob the Bar Mitzvah Boy Explains Passover, Hollywood Game Night with Taraji P. Henson, Vlog with Taraji P. Henson, Sesame Street Promo, Their Own League, and Connectatron
| Name | Type | Role | |
|---|---|---|---|
| Mumford & Sons | Musical Guest | ||
| Taraji P. Henson | Host | ||
| David Rudman | Guest Star | Cookie Monster | |
| Caroll Spinney | Guest Star | Big Bird | |
| Billy Crystal | Guest Star | ||
| Joey Mazzarino | Guest Star | Murray Monster | |
| Nikolaj Coster-Waldau | Guest Star | ||
| Martin P. Robinson | Guest Star | Mr. Snufflepagus | |
| Leslie Carrara-Rudolph | Guest Star | Abby Cadabby | |
| Eric Jacobson | Guest Star | Bert | |
| Ryan Dillon | Guest Star | Elmo | |
| Matt Vogel | Guest Star | Count von Count |