The second Roadtrip begins with three friends from Stevensville, Montana. Aaron, Liz, and Autumn, Team "Poor Lazy Overachievers," want to get out of the "velvet coffin" of their small town. They begin their Roadtrip across the US in Los Angeles. Their first interview is with Kary Mullis, Nobel Prize-winning chemist and author of Dancing Naked in the Mind Field.