The weather is hot and steamy as Shannen and Holly arrive in Clarksdale, home of Muddy Waters and the Delta Blues. Shannen soon learns to play the harmonica, and, at Abe's BBQ, they get to taste some of the best ribs the South has to offer. The girls' search for the best of the blues takes them to the home of musician James 'Super Chikan' Johnson, to the famous Ground Zero Blues Club, and to one of the last authentic Mississippi jukes, Po' Monkey's.