The remaining Round of 16 matches conclude in the 2006 National Heads-Up Championship, with a $500,000 top prize on the line. Daniel Negreanu and T.J. Cloutier battle in the feature Hearts match-up. Michael Mizrachi reveals the origins of his nickname as he faces Sammy Farha. In the Diamonds bracket, Ted Forrest challenges qualifier Ernie Durack, while David Grey and Shawn Sheikhan battle as well.
| Name | Type | Role | |
|---|---|---|---|
| Oliver 'Ali' Nejad | Host | Himself - Tournament MC | |
| Matt Vasgersian | Host | Himself - Commentator | |
| Gabe Kaplan | Host | Himself - Commentator | |
| Kathryn Tappen | Host | Herself - Commentator |