Shayne's secretary, Lucy Hamilton (Patricia Donahue) and his friend, newspaperman Tim Rourke (Jerry Paris) try to figure out how two voodoo dolls spell murder in the premiere episode.
Things look black for Shayne when he wakes to find Nora Carroll in his apartment and Nora's husband dead on the next floor.
Julie London guest stars as a young woman whose dog dies after eating creamed chicken specially prepared for her spinster sister-in-law.
Reporter Ned Brooks has been murdered, and the evidence points to Tim Rourke. At least politician Jim Gardena is doing his best to pin the rap on him.
Mike is hired to investigate a suspicious death that the police have already ruled as accidental. When his activities threaten the election campaign of a would-be state attorney, the career of a prominent doctor and the insurance investigator who approved the claim for payment, he is slugged, drugged and framed for murder.
Shayne investigates a murder and a fortune in missing bonds.
Mystery writer Chris Fowler asks Shayne to trace poison pen letters accusing college faculty members of various crimes and threatening to expose them.
Fred and Nan Palmer have bought an old house which is fine by day but a fright at night. When unexplainable lights and noises continue to emanate from their basement, they hire Shayne to find the source of the disturbance.
PILOT
After gumshoe Mike Shayne is hired by a millionaire to keep his daughter away from gambling and gamblers, he becomes involved in the murder of a racetrack tout.