Four couples face the most difficult time in their marriage as each wife has just learned her husband has decided to become a woman. Relationships get redefined as each couple delves into the confusion, disappointment & uncertainty surrounding them.
Stacy introduces Les as Leslie to their friends. After a big fight with Cindy, Troy goes to therapy. Jennifer tells neighbors that Larry has a major announcement. Beverly is crushed when she learns her husband of 22 years is going to live as a woman.
With Jennifer's support, Larry comes out to their neighbors at Ladies' Night; Troy tells Cindy he's going to get a makeover to look more like Lucy; Stacy and Leslie get romantic; Beverly tries to chill out, and Karen heats things up with a fancy new hairdo.
Troy goes to a club as Lucy, but it fuels a fight with Cindy; Jennifer gets emotional after taking Lawren to get women's clothes and her hair done; Stacy and Leslie's investigation of facial feminization is followed by a surprise romantic proposal.
Cindy and Troy's relationship is tested; Stacy and Leslie stress over finances and deal with a new health concern; a nervous Beverly hopes to reconnect with her and Karen's eldest child, Cas, also transgender, who comes home for a visit.
Stacy and Leslie face potentially dangerous health issues while preparing for their child's birth. Beverly, Karen, and Cas experience an emotionally explosive therapy session. Cindy and Troy try to make their relationship work.
Cindy begins to open up her mind to Troy's transition, but draws a line when it comes to sex. After a stressful labor, Stacy delivers her baby, and Leslie heads off to surgery. Jennifer convinces Lawren to come out to her mother.