Meet Zoe, six, who has brittle bone disease and suffers painful bone fractures easily.
Twin girls Abigail and Isobel were diagnosed with Down's Syndrome at birth.
Lindsay was born with no arms or legs - but competes in weightlifting competitions.
Nikki was born with two vaginas, causing prolonged periods and numerous miscarriages.
Meet autistic twins Jacob and Samuel and their parents.
Italo lost both legs when he was hit by a train; now he's a professional skateboarder.
If 17 year-old Liam falls asleep, he dies.
Born with diastrophic dwarfism, Rich Willis has a serious passion for powerlifting.
Tess Daly is completely paralysed but tens of thousands follow her beauty blogging.
Kaden Casebolt, 5, has Osteogenesis Imperfecta, meaning his bones can break from sneezing.
The nine-year old with a condition so rare it doesn't have a name.
Amanda has a rare disorder that means she constantly feels sexually aroused.
Michelle, who has a rare genetic disorder, is 20, but regularly gets mistaken for a child.
Despite daily battles with her allergies, Natasha has won 19 British gymnastics titles.
Leo struggled to accept his albinism as a child, but has grown proud of his unique looks.
When Emilly sings, her Tourette’s disappears.
Emily is currently living with a feeding tube and pursuing a passion for beauty blogging.
Five year-old Finley, who has cerebral palsy, is a social media star.
Adalia Rose was born with progeria, a rare condition that causes her body to age faster than normal. Adalia celebrates 11th birthday - a milestone year for her.
When Lauren was diagnosed with pulmonary arterial hypertension as a child, she and her mother Tracy knew just how serious it was.
Belle Hutt is 23 and suffers from severe narcolepsy. It’s a condition that causes her to fall asleep up to 15 times a day, as well as producing hallucinations.
Michael has Down's syndrome but his twin sister Julia doesn't. This makes them of the rarest sets of twins in the world.
Teenager Sohana has epidermolysis bullosa. Sohana lives in excrutiating pain from the skin condition and goes to great lengths to protect her fragile 'butterfly' skin.
19-year-old John was caught in a house fire at four years old. Most of his body is covered in burn scars and he has had to have over 80 operations to reconstruct his face.
Born conjoined, Kendra & Mailyah had surgery to separate them when they were four.
Piyah was born with half a body and male and has now transitioned to female.
Trevor is 17 and has one of the most extreme cases of Tourette’s in the world.
Alex (24) has Spinal Muscular Atrophy but feels she can still be glamorous and sexy.
Teenager Natalia was born with a rare disease which means her body is absorbing her bones
Carli has a disease that has caused her muscles, tendons and ligaments to turn to bone.