Dave welcomes late night talk show host Conan O'Brien, musical guest Regina Spektor, and musician John Mayer sits in with Paul Shaffer & the CBS Orchestra. Conan O'Brien tells Dave about the differences between himself and Jay Leno. Conan O'Brien tells what happened when his son had a hunger fit before meeting President Obama.
| Name | Type | Role | |
|---|---|---|---|
| Conan O'Brien | Guest Star | ||
| Regina Spektor | Guest Star | ||
| John Mayer | Guest Star |