Lia and Mateo are happy to finally gain their freedom as mortals on the night of the solar eclipse. With their former leaders completely losing their powers, La Liga Unida elects Frederick as its new commander. Unknown to Frederick, however, Sandrino and his coven of rebel vampires are brewing up a plan to destroy the council. Meanwhile, Malia crosses paths with Tristan. As the two shake hands, the La Liga Unida's seer, Jethro, receives a premonition about the young children's fate.
Jethro's prophecy sends La Liga Unida into a frenzy. Despite the threat of losing command once Lia and Mateo return to the council, Frederick vows to protect Malia at all costs. Meanwhile, Jethro searches for the former leader of the Lunas, Tonio, upon realizing that the soldier's child plays a role in the prophecy. However, Jethro soon comes face-to-face with Malia's destined adversary, Sandrino. Aware that the child of the strongest vampire and the chosen werewolf will spell his demise, Sandrino becomes hell-bent on killing Malia.
Threat arises to those with wolf blood when Sandrino initiated the search for the daughter of Mateo and Lia. Sandrino and his forces eliminate a pack of werewolves and kidnap a seven-year-old girl, as a threat to La Liga Unida for not revealing Mateo and Lia's location. Tristan crosses paths with two people of pale skin color and bloodshot eyes.
Tristan's father, Tonio, is killed by vampires as he sacrificed himself for Tristan's safety. Mateo made a weighty decision when they met Sandrino which is to become a vampire again. Lia also risked her own life in exchange for the safety of Malia. The Luna, werewolves, and vampires protecting Malia are all killed by Sandrino and his forces including Clarisse, Benjie, and others. Malia was able to escape under Baristo's protection. Using his power of illusion, Sandrino manages to deal a devastating blow on Mateo and Lia, leading to them both dying while holding hands.
Despite being defeated by Supremo, the hopes of La Liga Unida were renewed when they met the chosen one, Malia. Tristan also promoted himself to vengeance against the vampires, the reason why his father died. 14 years after, Tristan and Malia are now grown ups. Tristan fights the group of robbers to recover the bag containing his cashbox. Malia grows up to be a skillful hunter.
Malia has mixed feeling of pressure and forebode in her upcoming 21st birthday, as it is the time for her real power as the chosen one to appear. To prepare, Malia resolves to fulfill the prophecy as she begins her training. Malia and Jake face off as they reach the final match. In her hands also lies the freedom of both werewolves and vampires. Apple tells Tristan that she wants to study in Manila.
Members of La Liga Unida celebrated because of the good news that Verusca delivered to them as the lives of many people were at risk because of the Supremo search for Malia.
Isang mahirap na desisyon ang pilit na gagawin ni Ningning (Kristel Fulgar), samantalang patuloy ang paghihinala ng mga kaibigan ni Tristan (Daniel Padilla) kay Miyo (Kathryn Bernardo).
Kasabay ng muling pagkikita nina Malia at ng kanyang mga kasama ay ang isang magandang balita na magbibigay ng pag-asa para dumami ulit ang kanilang bilang.
Nangamba si Tristan sa kaligtasan ng kanyang pamilya nang bigla niyang makita si Lemuel. Nabuhayan rin ng pag-asa si Malia nang magkita ulit sila ni Jake.
Naghihinala na si Betty sa kakaibang ikinikilos ni Tristan at sumali na rin si Nognog sa grupo ni Supremo.
Ipinadala ni Prof T. ang mga Moonchasers sa isang boot camp para maging handa sila sa mga labanan sa susunod nilang mga misyon. Nakaisip rin ng paraan si Malia kung paano siya makakapasok sa SMV Corporation.
Aksidenteng nag-krus ang mga landas nina Miyo at Supremo sa SMV Corp, kaya naman naisip ni Miyo na mag-apply ng trabaho sa nasabing kumpanya.
Nagkainitan sina Prof T at Tristan nang biglang magpakita ang binata sa headquarters ng Moonchasers at hindi pa rin sumusuko si Miyo sa plano niyang makapasok sa kumpanya ni Supremo.
Napasabak sa bakbakan sina Tristan at Miyo nang may manggulong lasing sa lugar nila at si Sen. Mallari ang magiging bagong misyon ng mga Moonchasers.
Pinasakay ni Supremo ang publiko sa kanyang bagong pakulo at naghahanda naman ng husto si Malia para sa pagkikita nila ni Omar.
Binalaan ni Tristan si Sen. Mallari na nasa panganib ang buhay nito dahil ito ang puntirya ngayon ng mga bampira. Nabasa rin ni Malia ang planong gawin sa kanya ni Omar, ang dalhin siya kay Supremo.
Mas kinilala ni Sen. Mallari ang mga Moonchasers at sa tulong ni Omar, napasok na ni Malia ang kuta ng mga bampira.
Sinugod ng mga tauhan ni Supremo sina Sen. Mallari at ang mga Moonchasers.
Walang panama ang mga Moonchasers sa lakas ng mga bampirang nakalaban nila, ilan sa kanila ang namatay at karamihan sa kanila ay sugatan.
Nalaman ni Supremo na may tumatraydor sa kanya at aalagaan ni Miyo si Tristan dahil hindi ito pwedeng umuwi sa pamilya niya.
