Jacob and Joshua: Nemesis Rising follows identical twins who could not be more different. Joshua is a free spirit, a party boy and exceedingly single while Jacob is focused, driven and involved in a long-term relationship. As singers the duo harmonize perfectly with Jacob leaning more toward pop and Joshua a little more toward rock n' roll. After uprooting themselves from their country home in Montana to Los Angeles, the twins find themselves at a critical crossroads professionally and personally. They need a hit record or they face being dropped from their label.
The twins return to Montana to "come out" to their parents.
After coming out to their family, the twin's parents start to digest the news. Jacob and Joshua discuss relationships while fly-fishing with their Dad and hang out with Jacob's ex-girlfriend. Will Jacob introduce his boyfriend to his religious family? Joshua has an emotional breakdown as they drive to the airport. Back in Los Angeles, Joshua lives the single life, while Jacob surprises Nick with a special anniversary present.
Jacob & Joshua return to Nashville to perform in front of a live audience for the first time in three years. Their rehearsal is rough and their clothing selection is questionable, which displeases their manager. Can they pull it together in time? The twins also visit Nick's family and Joshua's first boyfriend.
Now that the record label is behind Nemesis, the twins go before the cameras to shoot their first music video and album cover. When their opinions are ignored, Jacob & Joshua question how they will be represented. Their manager informs them that their first big publicity will be a cover story in The Advocate. As usual, the twins have differing opinions about being marketed as gay performers.
Jacob & Joshua find out that legendary performer, Barry Manilow, will produce one of their songs in a Las Vegas recording studio. Less than thrilled with the song selection, will their attitude ruin the performance? Instead of focusing on rehearsals, the twins explore Vegas and its gay nightlife. Will they be prepared for their recording session with Barry?
As their apartment lease expires, Jacob & Joshua realize their place is too small for the three of them. The twins perform at the Human Rights Campaign National Dinner in Washington, DC, and appear on MTV's "Total Request Live." How will each appearance affect their career, and, in the end, was coming out worth the risk?