Hoppy's friend Dennis owns a rich gold mine. Frazier who owns the adjoining mine and wants the Dennis mine, has Dennis killed. Hoppy steps in to take over running the Dennis mine and learns Frazier's men sneak into and work the Dennis mine at night. Hoppy captures one of Frazier's men only to be captured in return by Frazier and left to die in a burning building.
The U.S. Army asks Hoppy to investigate when a herd of horses desperately needed for the Spanish-American War is stolen from the ranch who was supposed to supply the herd. The ranch workers insist the horses were rustled by Mexican bandits, but the Mexican authorities claim that no herd of horses crossed the U.S.-Mexican border, legal or illegal.
The foreman at Lazy J Ranch is behind the rustling of the ranch's own delivery of cattle.
Hoppy goes to town and helps a widow when con-men try to take her herd.
Local ranchers scheme to protect their revenue when a new railroad line threatens their business.
Hoppy and his friend Lucky deliver a herd of cattle to a rancher in Argentina and fight off thieves.
Hopalong infiltrates a town run by crooks and discovers the chief is none other than Ma Burton.
Hoppy is up against a phony European "baron" and his gang of horse thieve
Hoppy and Lucky arrive in a troubled mining town and hunt for gold thieves.
While Hopalong tries to foil a Wells Fargo stagecoach robbery, Lucky falls in love.
Hoppy and new sidekick California Carlson head to California to help out Lucky Jenkins.
Jane Travers enlists Hoppy and Lucky to help ferry a gold shipment across the Mexican border.
Hoppy, Lucky and California search for a mine owned by Trudy Pendleton after it was taken.
Hoppy and the Bar 20 boys are temporarily deputized and asked to wrestle control of the town back.
A lumberman is pitted against despoiler capitalist Preston Yates and his hired goons.
A former Bar 20 cowhand needs to stop the rustlers raiding his land.
Hopalong, California and Johnny pose as English detectives to find disappearing cattle.
A wealthy horse owner invites Hoppy to accompany him to Saudi Arabia to purchase prize horses.
Hoppy leads an expedition to find a gold cache among ancient Native ruins.
Johnny is accused of robbing a bank and Hoppy tries to prove his innocence.
A bandit who robs both Americans and Mexicans is causing each side of the border to blame the other.
Sheriff Hoppy must find a way to bring a group of outlaws outside of his jurisdiction to justice.
Three Texas Rangers try to investigate kidnapped Mexicans being used as forced labor.
As rustled cattle have mysteriously disappeared, Johnny sends for his friend Hoppy.
While oil drilling, Hoppy and California discover an underground well.
Stagecoach robbers take the money Hoppy was going to use to buy cattle.
A bad guy named Mark Foster murders the heir to a cattle ranch and puts an imposter in his place.
Hoppy is blamed when his falsley accused young friend is killed while trying to escape from jail.
A gang of outlaws is using force to become possessors of every ranch in the area.
Julie's husband has been murdered and land agents want her to sign away her property rights.
Hoppy's ranch is threatened by rustlers; Hoppy and the gang oblige as usual.
When he runs for sheriff, Hoppy is beaten by Jerry Doyle, voted for by the town's crooks.
A wounded girl knows the way to stolen gold.
The son of an Army friend is about the join an outlaw gang.
Someone tries to kill California Carlson and his kin during the reading of a will.
Treasures interred with the dead are stolen during a scientific study of Indian burial grounds.
Hoppy tries to save a church from being pillaged.
A bank robbery ruins Hoppy's holiday in Mesa City.
One of Hoppy's Bar 20 ranch hands is tricked into participating in nefarious activities.
Hoppy investigates mysterious deaths linked to a room at the Last Chance Inn.
Hopalong investigates a rash of mysterious accidents on a railroad line.
Hoppy sets out to catch a chronic breaker of saloon windows.
Hoppy protects a professor and his daughter from claim jumpers.
Hoppy tracks a counterfeiting ring.
A likable young man idolizes an infamous criminal.
Someone shoots at Hoppy and Red in a deserted town.
Hoppy and Red resolve to help local ranchers against an exploiter.
Drought threatens cattlemen and the banker extending their credit.
A banker asks Hoppy to trap robbers hijacking gold shipments.
A Southerner buys a wagon in which thieves hid money.
Hoppy goes to Mexico to investigate mass murders of Chinese workers.
A Gypsy seeks to clear his father of charges of robbery.
Saboteurs try to prevent Arizona's first telegraph line.
Gold thieves frame a young friend of Hoppy's for murder.
Hoppy's lawyer nephew represents a bank robber.
An evil ranch foreman tries to provoke a range war by playing two cattlemen against each other while helping a gang to rustle the cattle. Each cattleman blames the other for missing cattle. With the help of Bill Cassidy (Hop-along, because of an earlier bullet wound) and Johnny Nelson, the warring cattlemen join forces to do in the outlaws.
The grandson of the notorious bandit El Toro witnesses the murder of his parents by men trying to hijack the gold they were carrying. After El Toro saves the life of Hop-a-long Cassidy, Cassidy agrees to find and protect the boy, who is in hiding from the killers, whom he can identify. Cassidy and his partner Johnny Nelson, with the help of friendly bartender Spike, try to save the boy and bring down the man behind the gold robbery.
Hoppy returns to find Johnny in trouble. Buck Peters has been shot by Porter who made it look like Johnny did it. When Johnny flees he runs into Linda. He takes a liking to her only to learn her father Shanghai is one of Porter's gang. Going after Shanghai, he gets captured by the gang and Porter now plans to kill him. But Hoppy is near by and Johnny will get unexpected help from Shanghai.
When a miner is murdered before he can file his claim, Editor Saunders sends for Hoppy. Now the new Marshal, Hoppy learns Lilli Marsh owns the murdered miner's claim and her henchman Blackie was the killer. After Hoppy and the ranchers take care of Blackie's gang, Hoppy goes alone to face Blackie and Lilli.
When Hoppy agrees to lead a large cattle drive north he runs into lots of trouble. First Anderson and Wilson join the drive to do what damage they can. Then Lewis and his men posing as Tail officials try to cut out part of the herd. When Hoppy sees through this ruse, they rustle some cattle and burn the camp.
Officials on both sides of the border are after an outlaw gang led by the Fox. They devise a plan where Hoppy is supposedly kicked out of the Rangers to become an outcast. When the Fox shoots his own gang leader, the famous ex-ranger Hoppy is recruited to replace him. Hoppy eventually realizes that the Fox is posing as the town idiot Loco. But the Fox is also on to Hoppy and uses Windy and little Molly to set a trap to for him.
The ranchers are having their cattle rustled and it looks like Indians from the reservation are responsible. Hoppy captures rustler Lone Eagle only to have him shot before he can talk. The Indians capture Hoppy thinking he was the killer. But Hoppy tells the Chief that Ranger Andrews is the rustler and probably killed Lone Eagle. If he can be allowed to retrieve Andrew's gun, the bullets will match.
Hoppy arives posing as an outlaw to avenge his brother's killing by Plunkett. After robbing a train and killing Plunkett, he gets to meet the boss known as the Lone Wolf and lead his next job. Seeking help from Stoneman to capture the outlaws, he realizes too late that Stoneman is the Lone Wolf and is captured.
On a cattle drive Hoppy, camp cook Windy, companion Lucky, and young Artie Peters encounter an eccentric professor. The professor professes to be searching for the evolutionary missing link, but in reality he is a cattle rustler who uses his dynamite to scatter the cattle in order capture some of them.
Lorna Drake arrives from England to take over the ranch. Although she and Hoppy argue most of the time she takes a liking for Hoppy, angering her fiance Ronald. This enables Scar to enlist Ronald's help in his plan to kill Hoppy. But when Hoppy foils that plan a forest fire develops endangering Lorna.
Hopalong Cassidy, boss of the BAR 20 ranch in Texas, rides down the New Mexico cattle country in response to an urgent message from his lifelong sweetheart, Nora Blake, who is in serious trouble. Before he, "Lucky" Jenkins and Pappy can reach her ranch, they are stopped by Clay Allison, a cattle-rustler who is in almost complete control of the district, and wants to extend his holdings by seizing Nora's cattle and driving her out.
Belle Starr has just returned from prison to take over her ranch where her foreman Ringo who is rustling cattle. He is after the herd and has planted his man Twister there. When Hoppy finds the cattle stampeded by Twister, he secretly marks them hoping this will lead him to the rustlers and their buyer.
Some years before, a vicious criminal and master of disguise known as 'The Fox' is captured by Rurales Colonel Gonzalez and Hoppy working undercover. When 'The Fox' escapes from prison, he vows to exact vengeance from the two lawmen. He lures Cassidy south of the border with a forged letter from Gonzalez and murders Gonzalez in cold blood. Aiding 'The Fox' in his plans is his sister Janet, to whom the chivalrous Hoppy finds himself attracted.
The local school is causing Hoppy problems. First Bar 20 cattle are stolen when Hoppy investigates a problem there. Then the new teacher arrives and disrupts the routine of the Bar 20 hands. Later with the Bar 20 hands at graduation, the rustlers are poised to strike again. But there is dissension among them and this will lead to the break that Hoppy needs.
Keller buys Marsh's cattle and then murders him to retrieve the money. But Ann Marsh remembered some of the serial numbers and this is the clue that Hoppy needs. He arrives posing as a dude. He also poses as a novice poker player and this brings in a few of the stolen bills. When he realizes Keller is the one he is after, he wins back all the money at the poker table. He escapes from Keller's saloon but Keller and his men head out after him.
Hoppy goes undercover as a gambler from the East when Bar 20 cattle are stolen by unknown rustlers. Brennan/Talbot are twin brothers (one a casino owner, the other a rancher) and Hoppy believes they provide alibis for each other while one is out committing crimes. Hoppy gets a job in the casino to learn more but is exposed when a gambling gunslinger notices him.
Town Marshal "Windy" Halliday sends for his old Bar-20 Ranch friends, "Hopalong" Cassidy and "Lucky" Jenkins, to help fight a gang of outlaws led by "Stiff-Hat" Bailey. Cassidy becomes interested in Mary Joyce, whose ranch is the main target of the Bailey gang. Things are complicated by the fact that Mary's husband, "Rusty" Joslin, and escaped convict, is tied up with the outlaws.
Having to herd their cattle over Buck Collin's land, the ranchers are building a railroad spur to avoid paying his fees. To stop them Collins has him men rob the stage of the payroll money and also disrupt the construction. But Hoppy has a plan. He lets the Deputy know when the stage will be robbed and then he robs that stage. Collins men try to rob him just as the Sheriff arrives. When Hoppy breaks them all out of jail he is accepted into the gang.
Marshal Hoppy has been called in to investigate payroll robberies and arrives posing as Marvelo the mind reader. When Lucky arrives Hoppy has him pose as the expected Marshal. Hoppy works his way into the gang led by Ma Burton and sets a trap for them. But once again Lucky slips up revealing the masquerade and Hoppy finds himself a prisoner in a burning building.
Hoppy, Lucky and Speedy are driving a herd of mustangs to the town of Blue Sky, where they are to be delivered to Jeff Chapman, the owner of the Bar 20 stage line, when they come upon Jeff's runaway stage. The stage has just been robbed by Smiley and his gang of singing outlaws, who have shot Jeff and left him to die.
With the local vigilantes unable to combat the lawlessness, Forbes sends for Hoppy. Dry gulched on the way, Hoppy realizes the bad guys were tipped off and he, Lucky, and California arrive posing as bad men. Hoppy suspects Logan and sets up a silver shipment to trap him. When the silver disappears, Hoppy looks like a double crosser and is trouble. Not only has his identity been revealed sending gummen after him, but Lucky is about to be hung as an accomplice.
Brent's cattle are being rustled and he has sent for Hoppy who arrives with California and Johnny. The three pose as dude English detectives but their identity is quickly revealed when they have to fight off the rustlers. When Hoppy and California finally find the rustler's hideout they also find themselves prisoners.
Burton is after Clark's ranch. He gets the banker to refuse to renew Clark's note and then sends his men to rustle his cattle. Hoppy is Clark's new foreman and is on to Burton's scheme. But just as he learns of the rustling and is about to go after the gang, the Sheriff arrives and arrests him for hiding Johnny who has been accused of robbery.
After Hoppy helps round up the Trilling gang, Trilling breaks his men out of jail and they rustle the Bar 20 herd for revenge. When Hoppy gets the herd back, Trilling posing as a Marshal not only gets the herd again, he gets the Sheriff to jail the Bar 20 gang. Getting help from the Sheriff's daughter, Hoppy and pals start out once more after Trilling.
Sue Harmon gets Hoppy and his friends to join their expedition looking for Indian artifacts. Expedition leader Atwood makes a deal with nearby cattle rustler Morgan to loot the Indian treasures instead and sell them. Hoppy is on to their plan and pretending to leave follows them. Not only is he outnumbered by Morgan's men, but California has himself about to be sacrificed in an Indian ritual.
Hoppy, California, and Lucky travel to Mesa City for a short vacation. California buys new clothes and carrying his old ones in a suitcase, bumps into escaping bank robbers in the dark. His suitcase gets switched with that of the robbers and he is seen with the money. Hoppy must find the money that has mysteriously disappeared and also the robbers so that he can clear California who is now in jail.
After receiving money for delivering a large herd, Hoppy, California, and Lucky retire to an inn for the night. The next morning both Lucky and the money are gone. At first Hoppy suspects Blaney and his gang but later realizes Doc Richards is responsible. He and his mysterious concoctions have put Lucky under a hypnotic spell and Hoppy and California set out to find him.